{"id":"W2068837546","doi":"10.1016/j.bmc.2007.07.021","title":"Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: Design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Moiety; Prodrug; Aryl; Nitric oxide; Cyclooxygenase; Stereochemistry; Enzyme; Organic chemistry; Biochemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002447481,0.0007398951,0.001106682,0.0002162997,0.0003250153,0.00004595928,0.0001704687,0.0004697154,0.00009413427],"category_scores_gemma":[0.004000505,0.0006112884,0.0001766006,0.0007495807,0.0005316043,0.0002170504,0.0001572495,0.00078572,0.00003377654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003851657,"about_ca_system_score_gemma":0.0005212837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000453814,"about_ca_topic_score_gemma":0.000003338703,"domain_scores_codex":[0.9960176,0.00007096362,0.001028033,0.0009678521,0.0008953745,0.001020204],"domain_scores_gemma":[0.9964435,0.001006641,0.0004250281,0.0006891637,0.000503447,0.0009322637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007746068,0.0002582226,0.003366529,0.002012744,0.0002917207,0.001312106,0.0005983475,8.047124e-7,0.9879773,0.000003536687,0.0008923181,0.002511819],"study_design_scores_gemma":[0.0035419,0.0001206946,0.03046841,0.001992704,0.0008582242,0.002461716,0.001872737,0.00006550658,0.9575163,0.00005033025,0.0003731217,0.0006783949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986345,0.009651076,0.001922945,0.0005754303,0.000231654,0.0008074088,0.00001431759,0.0002735972,0.0001785757],"genre_scores_gemma":[0.9940965,0.0008088784,0.001931615,0.0008966437,0.001705269,0.00007578951,0.00003424407,0.0001349361,0.0003161051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03046099,"threshold_uncertainty_score":0.9996338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675569726820585,"score_gpt":0.2805958644438118,"score_spread":0.2538401671756059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}