{"id":"W2068837546","doi":"10.1016/j.bmc.2007.07.021","title":"Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: Design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Moiety; Prodrug; Aryl; Nitric oxide; Cyclooxygenase; Stereochemistry; Enzyme; Organic chemistry; Biochemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631533,0.0003517294,0.0002236367,0.0001428483,0.00009725329,0.0001224962,0.0003231015,0.0002262397,0.001087863],"category_scores_gemma":[0.0001000238,0.0001180182,0.000136074,0.00007843153,0.0001372309,0.0001698786,0.0001130606,0.0002256849,0.0004031207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001521147,"about_ca_system_score_gemma":0.0001615421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534665,"about_ca_topic_score_gemma":0.0005628336,"domain_scores_codex":[0.9999491,0.000007852458,0.000004453124,0.000009351118,0.0000109985,0.00001826746],"domain_scores_gemma":[0.9999572,0.000006933706,0.00001444534,0.000004207058,0.000005897567,0.00001143477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002815824,0.00009179415,0.00007235545,0.0001052244,0.000006555382,0.0002863299,0.00002976984,0.0003936875,0.9895998,0.0005321296,0.0001384836,0.008462146],"study_design_scores_gemma":[0.0002041123,0.002536995,0.0008256822,0.000008881119,0.00002205978,0.0005621505,0.00001612403,0.0008879897,0.9882775,0.00008728306,0.00656037,0.00001095056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669467,0.004331077,0.02042809,0.0001689232,0.0001297731,0.0002756251,0.000365577,0.0002494874,0.007104717],"genre_scores_gemma":[0.9805517,0.001809326,0.01188128,0.00008944539,0.00002337534,0.0001233296,0.000314671,0.00001827078,0.005188629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001087863,"threshold_uncertainty_score":0.003639281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675569726820585,"score_gpt":0.2805958644438118,"score_spread":0.2538401671756059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}