{"id":"W2068852170","doi":"10.1074/jbc.m212364200","title":"Isolation, Structural Characterization, and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced byPaenibacillus kobensis M","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Heptose; Stereochemistry; Chemistry; Biochemistry; Amino acid; Residue (chemistry); Mutant; Amide; Threonine; Biosynthesis; Polymyxin; Cyclic peptide; Peptide; Antibiotics; Gene; Serine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467537,0.0001919603,0.0003477384,0.00002584205,0.0000577017,0.00002724478,0.0001620727,0.0002293308,0.0000356771],"category_scores_gemma":[0.0006539046,0.0001330402,0.0001052996,0.00009265885,0.0002493232,0.00001322497,0.00004799892,0.0001315876,7.124091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001629563,"about_ca_system_score_gemma":0.00008267746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001013296,"about_ca_topic_score_gemma":3.168588e-7,"domain_scores_codex":[0.9987078,0.00008396072,0.0006179895,0.0002542053,0.0001371926,0.0001988793],"domain_scores_gemma":[0.9988142,0.00001180359,0.0005878097,0.0002134888,0.0002793929,0.00009333032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001639556,0.00003421284,0.08447737,0.00009344426,0.0000562275,0.000003416849,0.00002661027,0.000002279173,0.9149318,0.000007195337,0.0000296037,0.0001738881],"study_design_scores_gemma":[0.0003902051,0.0001650398,0.06722554,0.00007791615,0.00002234615,0.0002575621,0.0000970953,0.000006277497,0.9311141,0.00002071546,0.0004650226,0.0001581749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985055,0.0008762808,0.0002272013,0.00008972619,0.0000903642,0.0000933932,0.0000132955,0.000005023663,0.00009922506],"genre_scores_gemma":[0.9983501,0.0003432273,0.0008057797,0.00004723048,0.0001666442,5.222363e-7,0.00002573608,0.00001314343,0.0002475775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01725182,"threshold_uncertainty_score":0.5425223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460056083631281,"score_gpt":0.228766899714755,"score_spread":0.2141663388784422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}