{"id":"W2068852170","doi":"10.1074/jbc.m212364200","title":"Isolation, Structural Characterization, and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced byPaenibacillus kobensis M","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche Médicale; University of Alberta","keywords":"Heptose; Stereochemistry; Chemistry; Biochemistry; Amino acid; Residue (chemistry); Mutant; Amide; Threonine; Biosynthesis; Polymyxin; Cyclic peptide; Peptide; Antibiotics; Gene; Serine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008513914,0.0002608514,0.0001201145,0.000214578,0.0001215836,0.0001506718,0.00008593761,0.0001849557,0.0002481797],"category_scores_gemma":[0.0002270473,0.00008863303,0.0001615914,0.0002246343,0.0001271664,0.000206542,0.0001321753,0.0002938031,0.0001087462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125487,"about_ca_system_score_gemma":0.000153276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006306911,"about_ca_topic_score_gemma":0.000387439,"domain_scores_codex":[0.9999261,0.00001080099,0.000006477866,0.00001937181,0.0000230882,0.00001413551],"domain_scores_gemma":[0.9998747,0.00002054696,0.00004576537,0.00001274402,0.00002026191,0.00002594196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002530569,0.0000105727,0.0002999152,0.00001171936,0.000001170699,0.00003100255,0.000007680067,0.00003425535,0.9984811,0.000007141005,0.00000560288,0.001084523],"study_design_scores_gemma":[0.00001071046,0.0005638842,0.03146667,0.000009412101,0.00002049651,0.0007165897,0.00005932842,0.00150846,0.9632627,0.00003772233,0.002335689,0.000008370842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971479,0.0006621055,0.001608766,0.00003434396,0.000005511014,0.00001395465,0.0001806588,0.00001023517,0.0003366672],"genre_scores_gemma":[0.9943169,0.0005774997,0.003436914,0.00003386672,0.00001098045,0.00001453811,0.0007916576,0.00001490992,0.0008026981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006306911,"threshold_uncertainty_score":0.001254022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01460056083631281,"score_gpt":0.228766899714755,"score_spread":0.2141663388784422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}