{"id":"W2068866489","doi":"10.1515/hmbci.2010.009","title":"Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase","year":2009,"lang":"en","type":"article","venue":"Hormone Molecular Biology and Clinical Investigation","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Androstenedione; Dihydrotestosterone; Testosterone (patch); Androsterone; Chemistry; Reductase; Finasteride; Endocrinology; Internal medicine; Steroid; Androgen; Enzyme; Biochemistry; Hormone; Biology; Prostate; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659221,0.0004016052,0.0003110295,0.0003525937,0.0002022324,0.0003748049,0.0002186447,0.0001928074,0.001321827],"category_scores_gemma":[0.0001001982,0.0002065542,0.000546106,0.0004122684,0.0002414781,0.0001593914,0.0001190237,0.0005380004,0.0007647586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003451673,"about_ca_system_score_gemma":0.0003182671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001802916,"about_ca_topic_score_gemma":0.002687991,"domain_scores_codex":[0.9996927,0.00003252427,0.00003016604,0.00008200081,0.0001202625,0.00004236632],"domain_scores_gemma":[0.9998372,0.00003231796,0.00003913036,0.00002527526,0.00003151409,0.00003460795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004540131,0.00001327574,0.0002920212,0.00002745403,0.000004765239,0.00002461717,0.00001173389,0.00001431623,0.9990373,0.0000312147,0.00001434172,0.000483601],"study_design_scores_gemma":[0.000004672531,0.0001870565,0.00677369,0.000002693746,0.00001469267,0.0001746782,0.00002553899,0.0002847528,0.9911528,0.00001797442,0.001357164,0.000004245755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782601,0.005915968,0.01068435,0.0001237509,0.000115964,0.00006712059,0.001924966,0.0002482256,0.002659609],"genre_scores_gemma":[0.9712254,0.002540488,0.01561638,0.00009566995,0.00002769119,0.00008391846,0.00472769,0.00003786594,0.005644829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802916,"threshold_uncertainty_score":0.004421949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02339374125032412,"score_gpt":0.2975308152707946,"score_spread":0.2741370740204705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}