{"id":"W2068866489","doi":"10.1515/hmbci.2010.009","title":"Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase","year":2009,"lang":"en","type":"article","venue":"Hormone Molecular Biology and Clinical Investigation","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Androstenedione; Dihydrotestosterone; Testosterone (patch); Androsterone; Chemistry; Reductase; Finasteride; Endocrinology; Internal medicine; Steroid; Androgen; Enzyme; Biochemistry; Hormone; Biology; Prostate; Medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005107411,0.0001982031,0.0003200566,0.00008977936,0.00007219844,0.00001594675,0.0001206116,0.0002794037,0.000002877971],"category_scores_gemma":[0.0001020858,0.0001572141,0.00007662474,0.0001389385,0.0007378309,0.00002345976,0.00005118591,0.0001553491,8.278051e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005999746,"about_ca_system_score_gemma":0.0000528785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007163842,"about_ca_topic_score_gemma":0.00002868586,"domain_scores_codex":[0.9983285,0.000286534,0.0007087812,0.0003716482,0.0001186359,0.0001859118],"domain_scores_gemma":[0.9992062,0.00005403448,0.0003408809,0.0002167273,0.00007735371,0.0001047412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003493358,0.00009748916,0.04518476,0.0000283007,0.00004006037,0.000001375888,0.0005731256,0.0000110712,0.9513312,0.0003215323,0.00002071591,0.002041009],"study_design_scores_gemma":[0.00204269,0.001629802,0.213909,0.00001920573,0.00006886651,0.00001027173,0.0002050531,0.0002461644,0.7791837,0.002506278,0.00001408845,0.0001647946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948493,0.001675556,0.0007891623,0.002110912,0.00006043978,0.0004474128,0.00003901201,0.000006679938,0.00002155231],"genre_scores_gemma":[0.9972649,0.000793907,0.0002611559,0.001099072,0.00002626786,0.00001443183,0.0005227251,0.00001024485,0.000007309625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1721475,"threshold_uncertainty_score":0.6411003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02339374125032412,"score_gpt":0.2975308152707946,"score_spread":0.2741370740204705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}