{"id":"W2068889233","doi":"10.1089/cbr.2006.21.225","title":"Oncolytic Adenovirus-Mediated E1A Gene Therapy Induces Tumor-Cell Apoptosis and Reduces Tumor Angiogenesis Leading to Inhibition of Hepatocellular Carcinoma Growth in Animal Model","year":2006,"lang":"en","type":"article","venue":"Cancer Biotherapy and Radiopharmaceuticals","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Oncolytic virus; Cancer research; Survivin; Angiogenesis; Oncolytic adenovirus; Genetic enhancement; Downregulation and upregulation; Apoptosis; Hepatocellular carcinoma; Adenoviridae; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002265665,0.0003934359,0.0003328117,0.0003384424,0.0001122842,0.0001941798,0.0001559688,0.000223404,0.001020335],"category_scores_gemma":[0.0001076186,0.0001399085,0.0001922911,0.0001232353,0.0003131695,0.000208156,0.00009315455,0.0005196985,0.0002654716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003010176,"about_ca_system_score_gemma":0.0002177744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000559512,"about_ca_topic_score_gemma":0.0005498677,"domain_scores_codex":[0.9998775,0.00003292921,0.00001045022,0.0000200695,0.00002876624,0.00003034915],"domain_scores_gemma":[0.9999297,0.0000155501,0.00001853462,0.00001266662,0.000009349901,0.00001428139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316048,0.0000650311,0.0001167836,0.00003342799,0.000007124204,0.00003005999,0.00001032546,0.00006834589,0.9979832,0.0001772027,0.00004037407,0.001336462],"study_design_scores_gemma":[0.00002307193,0.0003533384,0.0005597238,0.00000235523,0.00001339049,0.0001054936,0.000006644615,0.0006062243,0.9970722,0.00003475342,0.001220873,0.000001925629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874111,0.003087427,0.007067177,0.0001572773,0.0000524276,0.00004440858,0.0001981057,0.0001661881,0.001815944],"genre_scores_gemma":[0.9916365,0.001707071,0.00315128,0.00002699672,0.00001180775,0.00003682291,0.0003168948,0.00001699165,0.003095641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020335,"threshold_uncertainty_score":0.003413379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281651847950419,"score_gpt":0.3200040272150378,"score_spread":0.2871875087355336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}