{"id":"W2068898170","doi":"10.1016/s0968-0896(03)00396-1","title":"iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Peptidomimetic; Chemistry; Moiety; Stereochemistry; Lactam; Amide; Carboxamide; Peptide bond; Amino acid; Peptide; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002011305,0.0001916875,0.0002189023,0.0001457234,0.00007978645,0.0001788045,0.0004043227,0.0001530962,0.002044203],"category_scores_gemma":[0.0002145937,0.0001079849,0.0001203655,0.0001100254,0.0001931176,0.0002145117,0.000124464,0.0004925249,0.0003889897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002168149,"about_ca_system_score_gemma":0.0001689412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003680049,"about_ca_topic_score_gemma":0.0005268332,"domain_scores_codex":[0.9999002,0.00002193889,0.000006567364,0.0000143777,0.00002629547,0.00003059141],"domain_scores_gemma":[0.9999098,0.00001663835,0.00002178635,0.00001016027,0.00001208774,0.00002955831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001649248,0.0001591382,0.000124441,0.0001039458,0.0000117088,0.0001800369,0.00004734472,0.0004193182,0.9881493,0.0007922672,0.0001606513,0.008202578],"study_design_scores_gemma":[0.00071424,0.007290093,0.002917676,0.00001695121,0.00004841114,0.0007859537,0.00005644252,0.001619573,0.9747812,0.0002235385,0.01152283,0.0000231251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871024,0.002564575,0.001928071,0.00009827749,0.00007971994,0.00007064189,0.0002732879,0.00006643328,0.007816613],"genre_scores_gemma":[0.9934611,0.001066569,0.001835791,0.00006064108,0.00003035924,0.00003498869,0.0003522595,0.00001300133,0.003145211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044203,"threshold_uncertainty_score":0.00683856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007276561170213886,"score_gpt":0.2093421799219715,"score_spread":0.2020656187517576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}