{"id":"W2068907151","doi":"10.1016/j.bbrc.2008.12.075","title":"PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1","year":2008,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"PTEN; Transcription factor; Phosphatase; Sp1 transcription factor; Dephosphorylation; Biology; Cancer research; Phosphorylation; Cell biology; Molecular biology; Signal transduction; Chemistry; Promoter; Gene expression; Gene; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998244,0.000650495,0.0003750471,0.0008444822,0.0003875746,0.0005753052,0.0004414665,0.000311868,0.003360064],"category_scores_gemma":[0.0002361115,0.0003538477,0.0005022472,0.000435865,0.0006811026,0.0004986421,0.0003419016,0.001023378,0.0009159986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007813423,"about_ca_system_score_gemma":0.000895558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002684382,"about_ca_topic_score_gemma":0.003112859,"domain_scores_codex":[0.9995537,0.00003582836,0.00003276289,0.00006744033,0.0001303376,0.0001798393],"domain_scores_gemma":[0.9998639,0.00001701753,0.00003630789,0.00001290038,0.00001378815,0.00005600645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004654196,0.0001381063,0.0002373528,0.00007209687,0.00001691029,0.0001092227,0.00002591745,0.0001074008,0.9953128,0.0006632953,0.0002735073,0.00257782],"study_design_scores_gemma":[0.00005287853,0.0003622053,0.002805824,0.0000045321,0.00004116802,0.000206583,0.00004994912,0.0008198923,0.9926988,0.0001621019,0.002787827,0.000008169995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848486,0.002463252,0.004174264,0.0004956601,0.000234648,0.00005058592,0.0008577774,0.0005166731,0.006358604],"genre_scores_gemma":[0.9905103,0.001596209,0.001763886,0.0001356523,0.00004210017,0.00005584626,0.0009623751,0.0000488053,0.00488477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003360064,"threshold_uncertainty_score":0.01124054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07456145070426026,"score_gpt":0.368249272329683,"score_spread":0.2936878216254227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}