{"id":"W2068922743","doi":"10.1016/j.ab.2011.11.017","title":"Electrochemical screening of the indole/quinolone derivatives as potential protein kinase CK2 inhibitors","year":2011,"lang":"en","type":"article","venue":"Analytical Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"University of Toronto","keywords":"Indole test; Chemistry; Phosphorylation; Electrochemistry; Combinatorial chemistry; Kinase; Biochemistry; Redox; Enzyme; Organic chemistry; Electrode","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282482,0.0002437661,0.0002398994,0.00003579015,0.00009249002,0.00001204859,0.0003766764,0.0003306675,0.00001382125],"category_scores_gemma":[0.0003344307,0.0001802125,0.000311659,0.0002846149,0.0005814376,0.000004873739,0.0002834012,0.0002466341,0.000001961091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001632586,"about_ca_system_score_gemma":0.00008146996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001391881,"about_ca_topic_score_gemma":0.000001326601,"domain_scores_codex":[0.9985205,0.00004882488,0.0003613216,0.000478624,0.0002542272,0.0003364999],"domain_scores_gemma":[0.9989972,0.00000736827,0.0001889837,0.0005339592,0.0001588585,0.0001136947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466202,0.0001262694,0.0008361065,0.000020769,0.0001153133,0.000004487381,0.000009871231,1.999194e-7,0.9979463,0.00005572233,0.0001692163,0.0005691008],"study_design_scores_gemma":[0.0002184813,0.0001478721,0.0003573271,0.00006089687,0.00007483511,0.0000235217,0.00006915763,0.0000414046,0.9983483,0.0002743053,0.0001488843,0.0002350364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956589,0.0001782432,0.002528235,0.0001646664,0.00001659251,0.0001362013,0.000008729274,0.00003230384,0.001276179],"genre_scores_gemma":[0.9941207,0.00001919189,0.004989961,0.0001339825,0.0001624904,0.000008969342,0.00004418143,0.00002069542,0.0004998966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461725,"threshold_uncertainty_score":0.7348853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102964448859252,"score_gpt":0.2453091575117946,"score_spread":0.2350127126258694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}