{"id":"W2068927532","doi":"10.1371/journal.pone.0029774","title":"Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine Efficacy","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; McMaster University; Bill and Melinda Gates Foundation","keywords":"Mycobacterium tuberculosis; In vivo; Tuberculosis; Tuberculosis vaccines; Ex vivo; Drug; Colony-forming unit; Medicine; Drug resistance; Vaccine efficacy; Microbiology; Immunology; Virology; Pharmacology; Biology; Vaccination; Bacteria; Pathology; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001362461,0.0004109057,0.0005851408,0.0005948486,0.0001691767,0.0006649981,0.000559676,0.001088424,0.001805648],"category_scores_gemma":[0.001106833,0.0003199925,0.0003069438,0.0004799194,0.0004092862,0.0006086418,0.0005659652,0.0008540839,0.0008466552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003728655,"about_ca_system_score_gemma":0.0003797946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003373369,"about_ca_topic_score_gemma":0.0006613529,"domain_scores_codex":[0.9992014,0.0002636665,0.00003600978,0.0001553779,0.0002858668,0.00005781317],"domain_scores_gemma":[0.9992461,0.0002822609,0.0001928779,0.0001169462,0.00010602,0.00005581992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008379476,0.00004128775,0.001671499,0.0002697162,0.000008681885,0.00005988816,0.00002712237,0.0001920939,0.9777842,0.000472479,0.0004206341,0.0189686],"study_design_scores_gemma":[0.00005096,0.001603827,0.01427422,0.0001791447,0.0000796222,0.002761578,0.0001055826,0.01153233,0.9460252,0.001034014,0.02230239,0.0000511496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5737679,0.05653817,0.3516623,0.001700417,0.0004598493,0.0008571096,0.002654119,0.002475143,0.009884912],"genre_scores_gemma":[0.8494116,0.01097123,0.1317338,0.0006516873,0.000107269,0.0004823579,0.001045132,0.0001189157,0.005478154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805648,"threshold_uncertainty_score":0.007205427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03712877266586275,"score_gpt":0.3163787588679952,"score_spread":0.2792499862021325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}