{"id":"W2068927532","doi":"10.1371/journal.pone.0029774","title":"Autoluminescent Mycobacterium tuberculosis for Rapid, Real-Time, Non-Invasive Assessment of Drug and Vaccine Efficacy","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; McMaster University; Bill and Melinda Gates Foundation","keywords":"Mycobacterium tuberculosis; In vivo; Tuberculosis; Tuberculosis vaccines; Ex vivo; Drug; Colony-forming unit; Medicine; Drug resistance; Vaccine efficacy; Microbiology; Immunology; Virology; Pharmacology; Biology; Vaccination; Bacteria; Pathology; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009004007,0.0002231171,0.0009560921,0.0001736844,0.00007124543,0.000008729608,0.00009541577,0.0001255671,0.0002750747],"category_scores_gemma":[0.0009148588,0.0001836783,0.0001450945,0.0001635627,0.00007276644,0.0001252228,0.0001087472,0.0001958281,0.00002956288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001052328,"about_ca_system_score_gemma":0.000116007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001363687,"about_ca_topic_score_gemma":0.000006489018,"domain_scores_codex":[0.9979558,0.0001330775,0.0005322016,0.0003326122,0.0003450052,0.000701317],"domain_scores_gemma":[0.9975612,0.001028675,0.0001520111,0.0004412849,0.0002935649,0.0005232586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004585164,0.004007926,0.3195207,0.001633321,0.001126189,0.000003111062,0.000246808,4.276065e-7,0.6617659,0.00005691121,0.01055742,0.0006227333],"study_design_scores_gemma":[0.003783837,0.0009559701,0.8850894,0.0005025587,0.0008091069,0.00001285256,0.00005803125,0.001174369,0.1070269,0.00001047887,0.0003759214,0.0002006256],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904367,0.0004151166,0.00002841225,0.006090943,0.00005345058,0.00145395,0.0000567255,0.00005049878,0.001414229],"genre_scores_gemma":[0.9847138,0.002493111,0.01080447,0.0003480093,0.0006394335,0.000189516,0.0001824222,0.00004386426,0.0005853502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5655686,"threshold_uncertainty_score":0.7490185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03712877266586275,"score_gpt":0.3163787588679952,"score_spread":0.2792499862021325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}