{"id":"W2068994140","doi":"10.1089/lrb.2009.0019","title":"mTOR Signaling in Lymphangioleiomyomatosis","year":2010,"lang":"en","type":"review","venue":"Lymphatic Research and Biology","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Lymphangioleiomyomatosis; PI3K/AKT/mTOR pathway; Discovery and development of mTOR inhibitors; Sirolimus; Tuberous sclerosis; Cancer research; Cell growth; RPTOR; Medicine; Everolimus; Biology; Bioinformatics; Signal transduction; Pathology; Internal medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003390791,0.0008438572,0.001236969,0.002265886,0.000316695,0.0008622927,0.0007730604,0.001053388,0.002135726],"category_scores_gemma":[0.0003051926,0.0002634495,0.0002650377,0.00237944,0.0005232931,0.001163735,0.0006215166,0.001376561,0.002520236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006477565,"about_ca_system_score_gemma":0.0008004016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000983167,"about_ca_topic_score_gemma":0.00168874,"domain_scores_codex":[0.999873,0.00002109302,0.00002227901,0.0000223035,0.00004884772,0.00001239089],"domain_scores_gemma":[0.9998902,0.0000359292,0.00002333854,0.000003782549,0.00003142329,0.00001522627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009774777,0.00006848891,0.0001938761,0.01101195,0.00007514183,0.0007775808,0.0000716178,0.0004571039,0.003442775,0.003502177,0.03053641,0.9497651],"study_design_scores_gemma":[0.00002704282,0.00008331101,0.001283816,0.002109672,0.00008478347,0.005643275,0.00007799797,0.0001288784,0.0008108151,0.00246704,0.9872609,0.00002246374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001258473,0.998661,0.0000787202,0.0001394021,0.0001214531,0.000002834018,0.000007145944,0.000005855696,0.0008576576],"genre_scores_gemma":[0.0008383458,0.9981225,0.0001175873,0.000113143,0.0001588763,0.00000399886,0.00001838715,9.698603e-7,0.0006261815],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002265886,"threshold_uncertainty_score":0.00714469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4045623985106134,"score_gpt":0.5108274786841435,"score_spread":0.10626508017353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}