{"id":"W2069029494","doi":"10.1016/j.jmb.2012.04.016","title":"Early Steps in Oxidation-Induced SOD1 Misfolding: Implications for Non-Amyloid Protein Aggregation in Familial ALS","year":2012,"lang":"de","type":"article","venue":"Journal of Molecular Biology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"SOD1; Amyloid (mycology); Chemistry; Superoxide dismutase; Protein aggregation; Protein folding; Biochemistry; Biophysics; Amyotrophic lateral sclerosis; Histidine; Oxidative stress; Cell biology; Biology; Enzyme; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004019492,0.0003188116,0.0002862094,0.0003079805,0.0003284928,0.0006220019,0.0002775913,0.0007217901,0.001903633],"category_scores_gemma":[0.0005218857,0.0002494317,0.0003799361,0.0001337887,0.0003338432,0.001248831,0.0003161405,0.0008837244,0.0004978072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004957202,"about_ca_system_score_gemma":0.0002192241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004294696,"about_ca_topic_score_gemma":0.0004859489,"domain_scores_codex":[0.9998965,0.00001818518,0.00001412985,0.00001919246,0.00002158307,0.00003033735],"domain_scores_gemma":[0.9996485,0.00008122921,0.00008407116,0.00004112254,0.0000581563,0.00008703352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004020857,0.000515409,0.01826849,0.0002261193,0.00004023421,0.002383251,0.0004350996,0.0007175509,0.9623827,0.003314026,0.0004589935,0.007237145],"study_design_scores_gemma":[0.000101643,0.001252374,0.1604791,0.00006923124,0.00008169501,0.003465273,0.0006649068,0.004217219,0.8202916,0.00628406,0.003037702,0.00005518643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943309,0.001870915,0.002180428,0.0002839462,0.00006361295,0.00003574824,0.0001505511,0.00003849878,0.001045379],"genre_scores_gemma":[0.9971042,0.0005300622,0.001085128,0.00006395417,0.00002350544,0.00001275422,0.000168977,0.000008987536,0.001002364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001903633,"threshold_uncertainty_score":0.006368279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04043505047567197,"score_gpt":0.3556352417862168,"score_spread":0.3152001913105448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}