{"id":"W2069054574","doi":"10.1016/j.nbd.2010.05.031","title":"Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1G86R","year":2010,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"SOD1; Amyotrophic lateral sclerosis; Mutant; Gene isoform; Superoxide dismutase; Wild type; Biology; Molecular biology; Mutation; Cell biology; Gene; Biochemistry; Disease; Oxidative stress; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430038,0.001332261,0.0008833114,0.001475259,0.0004038826,0.0008711856,0.0007831831,0.001206269,0.003840595],"category_scores_gemma":[0.0003486706,0.0006147326,0.0008049192,0.0005088445,0.001026776,0.001067532,0.000441602,0.002398574,0.001412268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000795877,"about_ca_system_score_gemma":0.0006353605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001742097,"about_ca_topic_score_gemma":0.002383244,"domain_scores_codex":[0.9993886,0.00007145598,0.0000944979,0.0001766437,0.0001198452,0.0001490067],"domain_scores_gemma":[0.9987331,0.0001645532,0.0004901227,0.0001486964,0.00007299009,0.0003905356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007884653,0.0001649748,0.0002430874,0.00003643546,0.00002333919,0.0001335728,0.00003995765,0.00008156235,0.9975148,0.0001952916,0.000106856,0.0006716097],"study_design_scores_gemma":[0.0001444383,0.0007564916,0.004918179,0.00002158903,0.00008392805,0.0008732295,0.0001021941,0.001338732,0.9894097,0.0001866369,0.002143129,0.00002163117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931682,0.001059004,0.001772617,0.0002725648,0.000171232,0.00005113464,0.001642633,0.0003241847,0.001538368],"genre_scores_gemma":[0.9791781,0.001058164,0.002508024,0.0001862141,0.00005096664,0.0001281172,0.002483816,0.000366604,0.0140399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003840595,"threshold_uncertainty_score":0.01284808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740031052139849,"score_gpt":0.3111825028851437,"score_spread":0.2837821923637451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}