{"id":"W2069059519","doi":"10.1186/ar4643","title":"Phenotypic consequences of TLR7-driven interferon and proinflammatory cytokine production in lupus","year":2014,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Lupus Research Alliance; Canadian Arthritis Network; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis Society; Central New York Community Foundation; Merck KGaA; Lupus Foundation of America","keywords":"Proinflammatory cytokine; Rheumatology; Medicine; TLR7; Phenotype; Systemic lupus erythematosus; Cytokine; Immunology; Interferon; Internal medicine; Inflammation; Biology; Immune system; Toll-like receptor; Genetics; Gene; Innate immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00162645,0.0001042047,0.0002272258,0.0003168725,0.0001249933,0.00001668974,0.0001423657,0.0001248934,0.0001359201],"category_scores_gemma":[0.0002770238,0.00009229143,0.00002939798,0.0001949397,0.0008034543,0.0002042017,0.00005101401,0.0003324306,0.00007811501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003134592,"about_ca_system_score_gemma":0.00007749096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001566572,"about_ca_topic_score_gemma":0.0001880844,"domain_scores_codex":[0.9978672,0.001151084,0.0003230656,0.000251681,0.00008291902,0.0003240002],"domain_scores_gemma":[0.9993107,0.0001946556,0.00007403804,0.0002422438,0.0001621861,0.00001622145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008835432,0.00004952006,0.003798783,0.0000154103,0.00002279698,0.00000190941,0.001189454,0.000002640105,0.7926089,0.001043322,0.0002448453,0.2001389],"study_design_scores_gemma":[0.002038105,0.001137545,0.01125308,0.0002392263,0.000001138062,0.00008329929,0.0003924047,0.000009737884,0.9554675,0.00192955,0.02732843,0.0001200215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895417,0.008336667,0.0000147362,0.0009651164,0.0002375084,0.0004861644,0.000001841234,0.00002434203,0.0003919111],"genre_scores_gemma":[0.9898399,0.0094588,0.00004121038,0.00001730037,0.00003612238,0.00006691431,0.0000172472,0.000011188,0.0005112989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2000189,"threshold_uncertainty_score":0.3763535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842577976198214,"score_gpt":0.2954263653342136,"score_spread":0.2670005855722315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}