{"id":"W2069059519","doi":"10.1186/ar4643","title":"Phenotypic consequences of TLR7-driven interferon and proinflammatory cytokine production in lupus","year":2014,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Lupus Research Alliance; Canadian Arthritis Network; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis Society; Central New York Community Foundation; Merck KGaA; Lupus Foundation of America","keywords":"Proinflammatory cytokine; Rheumatology; Medicine; TLR7; Phenotype; Systemic lupus erythematosus; Cytokine; Immunology; Interferon; Internal medicine; Inflammation; Biology; Immune system; Toll-like receptor; Genetics; Gene; Innate immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225973,0.0002975536,0.0002685788,0.000327878,0.000135352,0.0003244322,0.0001504,0.0004034269,0.001120998],"category_scores_gemma":[0.0001549862,0.0001805478,0.0002957422,0.0001116859,0.0002432347,0.0001474412,0.0002191309,0.0006547846,0.0004381688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997027,"about_ca_system_score_gemma":0.0001021721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001363784,"about_ca_topic_score_gemma":0.0001801793,"domain_scores_codex":[0.9997212,0.00005112946,0.00003962306,0.00004891894,0.000072913,0.00006619534],"domain_scores_gemma":[0.9997171,0.00003305436,0.00009138709,0.0000303954,0.00002635824,0.0001017462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001401791,0.0000151393,0.0005379224,0.00001597598,0.000003034544,0.0001068111,0.00001054893,0.00001638656,0.9988103,0.00003088423,0.000008201485,0.0003047194],"study_design_scores_gemma":[0.00006464465,0.001050092,0.03419848,0.00001741948,0.00004389148,0.003780182,0.0001025955,0.0006948212,0.9588082,0.0001563083,0.001073048,0.00001032814],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983076,0.0004207286,0.0005023337,0.00003271428,0.00000587105,0.00000758991,0.0002117446,0.0000265196,0.0004849679],"genre_scores_gemma":[0.9981605,0.0002431603,0.0005190905,0.00003213875,0.000005845816,0.00001842987,0.0003145745,0.00001145548,0.0006948295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001120998,"threshold_uncertainty_score":0.003750086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02842577976198214,"score_gpt":0.2954263653342136,"score_spread":0.2670005855722315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}