{"id":"W2069073856","doi":"10.1016/j.lfs.2006.09.035","title":"Effects of ischemia–reperfusion on the absorption and esterase metabolism of diltiazem in rat intestine","year":2006,"lang":"en","type":"article","venue":"Life Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Junta de Castilla y León; Ministère de l’Éducation, Gouvernement de l’Ontario; Consejería de Educación, Junta de Castilla y León","keywords":"Chemistry; Jejunum; Pharmacology; Diltiazem; Esterase; Metabolism; Ileum; Bioavailability; Pharmacokinetics; Prodrug; Ischemia; Superior mesenteric artery; Drug metabolism; Biochemistry; Internal medicine; Enzyme; Calcium; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005793091,0.001103407,0.001232029,0.0005912895,0.0004638466,0.0005013159,0.0005908222,0.0009623625,0.003884089],"category_scores_gemma":[0.0006709427,0.0005861321,0.0009274111,0.0005816217,0.001270949,0.001389767,0.0002586036,0.001966981,0.0006501944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008214149,"about_ca_system_score_gemma":0.0007593984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00247105,"about_ca_topic_score_gemma":0.002451533,"domain_scores_codex":[0.9997173,0.00005138462,0.00001652891,0.00004346457,0.00002315399,0.0001481429],"domain_scores_gemma":[0.999429,0.0001866173,0.0001048934,0.00009877362,0.00004335419,0.0001373147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.107532,0.0009865793,0.001493457,0.0003144588,0.0001323327,0.0007749638,0.0002604905,0.0004496537,0.8757493,0.0005535647,0.0003626008,0.01139043],"study_design_scores_gemma":[0.000737401,0.009688319,0.005973547,0.0000128641,0.0002620874,0.0002142243,0.0001257268,0.00119299,0.9805689,0.0001484187,0.001046858,0.00002878457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937333,0.003563892,0.0007814174,0.0002289119,0.0001285774,0.00003786624,0.0002991582,0.0001270109,0.001099754],"genre_scores_gemma":[0.9926742,0.002201542,0.0007677029,0.0001329754,0.0001381544,0.00004401353,0.0005827548,0.00003496731,0.003423767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003884089,"threshold_uncertainty_score":0.01299351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00788464618375835,"score_gpt":0.2292949550115855,"score_spread":0.2214103088278271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}