{"id":"W2069128890","doi":"10.1155/2011/174615","title":"Bioactivity Determination of Native and Variant Forms of Therapeutic Interferons","year":2011,"lang":"en","type":"article","venue":"BioMed Research International","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; McGill University; University of Ottawa; Health Canada","funders":"Health Canada","keywords":"Reporter gene; Interferon; Potency; Luciferase; Gene; Transfection; Robustness (evolution); Cell culture; Biology; Molecular biology; In vitro; Chemistry; Computational biology; Gene expression; Biochemistry; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008816802,0.00007863042,0.0001792527,0.0006406191,0.00004498503,0.000007477408,0.0001814184,0.00006415967,0.0004507325],"category_scores_gemma":[0.0002285843,0.00005539535,0.0000634723,0.0002621616,0.0007003619,0.0001118591,0.0001823575,0.0002221645,0.00000681288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005887924,"about_ca_system_score_gemma":0.0001202784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000332503,"about_ca_topic_score_gemma":0.00002302501,"domain_scores_codex":[0.9984591,0.0001029034,0.000246622,0.0001789734,0.0008051074,0.0002073168],"domain_scores_gemma":[0.9986835,0.0002573599,0.00007680495,0.0001276714,0.000747349,0.0001072835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006814296,0.002431948,0.06791703,0.0006026594,0.0008728815,0.0001138329,0.005409565,5.089295e-8,0.5389137,0.09294992,0.0003823043,0.2835918],"study_design_scores_gemma":[0.001955672,0.002733611,0.514142,0.0003161912,0.00002970707,0.0001773934,0.0008873576,0.002788587,0.4552159,0.0174727,0.004115641,0.0001652535],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750471,0.0001821273,0.0013347,0.001181549,0.0001708279,0.0003466833,0.00009297361,0.000008926191,0.02163515],"genre_scores_gemma":[0.9972017,0.000193783,0.001409163,0.00001660815,0.00005983813,0.00001876432,0.00002187643,0.000008127078,0.001070096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.446225,"threshold_uncertainty_score":0.4935204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1972651318915823,"score_gpt":0.4302844993146378,"score_spread":0.2330193674230555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}