{"id":"W2069134127","doi":"10.1074/jbc.m110.215061","title":"Kinetics of Activated Thrombin-activatable Fibrinolysis Inhibitor (TAFIa)-catalyzed Cleavage of C-terminal Lysine Residues of Fibrin Degradation Products and Removal of Plasminogen-binding Sites","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Plasmin; Fibrin; Chemistry; Fibrinolysis; Catalysis; Lysine; Thrombin; Kinetics; Enzyme kinetics; Binding site; Tissue plasminogen activator; Cleavage (geology); Biochemistry; Plasminogen activator; Stereochemistry; Active site; Enzyme; Amino acid; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006262347,0.0003544322,0.0004165962,0.0003095808,0.0001187877,0.0004192978,0.0003686965,0.0003582708,0.001084285],"category_scores_gemma":[0.0008518026,0.0002197634,0.0003407977,0.0003144637,0.0002112121,0.0004278402,0.0001623158,0.0008003913,0.000826555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752572,"about_ca_system_score_gemma":0.0002641097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128832,"about_ca_topic_score_gemma":0.0004957438,"domain_scores_codex":[0.9996004,0.00006444174,0.00003390159,0.00009212051,0.0001283254,0.00008080107],"domain_scores_gemma":[0.9991828,0.0003472284,0.0002103112,0.00005763071,0.0001218707,0.00008021265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006358881,0.0001269883,0.002645951,0.0001184735,0.00005925513,0.00009155724,0.0001213406,0.0006792034,0.9872943,0.0002812373,0.000141233,0.007804648],"study_design_scores_gemma":[0.00001512574,0.0003622316,0.01423017,0.00001122325,0.00002145157,0.00031396,0.00003999662,0.006308872,0.9773149,0.00009969992,0.001261005,0.00002128895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861223,0.003533322,0.008145582,0.00005442706,0.00002407083,0.00006034474,0.0005225578,0.00009851746,0.001438876],"genre_scores_gemma":[0.9908799,0.001386035,0.003899715,0.0000315856,0.000007973313,0.00006660895,0.0008674509,0.00003041987,0.002830235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128832,"threshold_uncertainty_score":0.00362736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03629440162180698,"score_gpt":0.241388684145862,"score_spread":0.2050942825240551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}