{"id":"W2069141087","doi":"10.1038/sj.onc.1206672","title":"The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell–cell adhesion and to suppress invasion","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Missense mutation; Cadherin; Germline; Mutant; Germline mutation; Mutation; Genetics; Wnt signaling pathway; Chinese hamster ovary cell; Cell adhesion; Beta-catenin; Cell biology; Cancer research; Cell; Cell culture; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006511461,0.0001548385,0.0001048633,0.00001784769,0.0002151861,0.00005009183,0.000211179,0.0001113047,0.00004424365],"category_scores_gemma":[0.0001177455,0.00009871677,0.00004235468,0.0001149788,0.00005629249,0.000003759846,0.0001176971,0.00008416861,0.00004040205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002429803,"about_ca_system_score_gemma":0.00006385238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642265,"about_ca_topic_score_gemma":0.00005501195,"domain_scores_codex":[0.9988615,0.0001425594,0.0002216667,0.000350867,0.0001798272,0.0002435858],"domain_scores_gemma":[0.9993313,0.00005141844,0.00006248351,0.0003402503,0.00009332239,0.0001212181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008258132,0.00002888441,0.0004001532,0.00001380705,0.00000780646,0.000002125727,0.0002284029,0.0001818959,0.9925025,0.000009017765,0.003278152,0.003264694],"study_design_scores_gemma":[0.000291404,0.0001465267,0.0004526929,0.000006666571,0.00001327699,0.000003518808,0.0001091075,0.00001597943,0.8847649,0.00007506702,0.1139773,0.0001435998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995144,0.001885929,0.0006406818,0.000745788,0.0002558353,0.0003858244,0.000006719606,0.000009333538,0.0009258596],"genre_scores_gemma":[0.9961433,0.0004545934,0.001115897,0.0004860254,0.000142299,0.00006230367,0.00003913663,0.00002120405,0.001535171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1106991,"threshold_uncertainty_score":0.4025553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008733183804301065,"score_gpt":0.2338044119150127,"score_spread":0.2250712281107117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}