{"id":"W2069144282","doi":"10.1016/j.stem.2009.04.003","title":"TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance","year":2009,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":249,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"Biology; Stem cell; Premature aging; Cell biology; Immunology; Physiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004212064,0.000543305,0.0006918909,0.0001215191,0.0002143144,0.00008336988,0.0004185778,0.0003088662,0.00008679078],"category_scores_gemma":[0.0000103665,0.0004735535,0.0002344964,0.0004104627,0.00006198339,0.0002060965,0.00007676001,0.000733644,0.0002486211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777762,"about_ca_system_score_gemma":0.0001211578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002371344,"about_ca_topic_score_gemma":0.000003034854,"domain_scores_codex":[0.9964808,0.0001643964,0.0007466478,0.0009279633,0.0006428433,0.001037372],"domain_scores_gemma":[0.9979284,0.00008787262,0.0004280839,0.000827196,0.000208845,0.0005196325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002398881,0.002135069,0.00874042,0.004752173,0.00004100011,0.0005616354,0.008465947,0.00002115032,0.8514483,0.00002125377,0.06910792,0.05446524],"study_design_scores_gemma":[0.003516743,0.0006602017,0.001845612,0.001472057,0.000164424,0.00008031366,0.00246532,0.0008523892,0.9622064,0.00002404099,0.02585217,0.0008603509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595251,0.005947656,0.0003156442,0.0006825898,0.0004736748,0.001523362,0.00003487477,0.000368014,0.03112906],"genre_scores_gemma":[0.9170994,0.0003852932,0.0004985243,0.001170894,0.0002337637,0.00002117616,0.00004923994,0.00007716999,0.08046459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1107581,"threshold_uncertainty_score":0.9997716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007212537887041692,"score_gpt":0.2169558755696693,"score_spread":0.2097433376826276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}