{"id":"W2069161621","doi":"10.1021/bi026555j","title":"Stoichiometry and Affinity of Nucleotide Binding to P-Glycoprotein during the Catalytic Cycle","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Nucleotide; Cyclic nucleotide-binding domain; Chemistry; Binding site; ATP hydrolysis; Adenosine diphosphate; Biochemistry; Adenosine triphosphate; Biology; Enzyme; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008963688,0.0001004011,0.0001653074,0.00004912927,0.00008146269,0.0000082078,0.00008803391,0.00006180203,0.0001181938],"category_scores_gemma":[0.00004393544,0.00007402211,0.00005083829,0.0002493054,0.00006700691,0.00001727944,0.00003052632,0.0001153617,0.00001649004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000287926,"about_ca_system_score_gemma":0.00001240902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001102831,"about_ca_topic_score_gemma":0.000002470499,"domain_scores_codex":[0.9993087,0.00000416786,0.0001591958,0.0001842148,0.0001736906,0.0001699976],"domain_scores_gemma":[0.9995145,0.00001559696,0.00004722704,0.0002814446,0.00002433593,0.0001169121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004190645,0.00006278334,0.003354385,0.0004220798,0.00002552938,0.00002546299,0.0001822962,0.00000113657,0.9952198,0.000009517837,0.00007747589,0.0005776016],"study_design_scores_gemma":[0.000464614,0.00002537481,0.01371835,0.0001755848,0.00003674244,0.00002843109,0.0002952898,0.00002419743,0.9849969,0.000008661158,0.0001339043,0.00009200068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964697,0.0004211951,0.00001316301,0.0004183005,0.00003750895,0.0001647045,0.00001640112,0.00003071542,0.002428276],"genre_scores_gemma":[0.9964734,0.00002908355,0.0003944614,0.00004331222,0.00006826199,0.000007579776,0.000004351717,0.00001473552,0.002964785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036396,"threshold_uncertainty_score":0.3018534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008933307763677957,"score_gpt":0.214982390287641,"score_spread":0.206049082523963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}