{"id":"W2069161621","doi":"10.1021/bi026555j","title":"Stoichiometry and Affinity of Nucleotide Binding to P-Glycoprotein during the Catalytic Cycle","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Nucleotide; Cyclic nucleotide-binding domain; Chemistry; Binding site; ATP hydrolysis; Adenosine diphosphate; Biochemistry; Adenosine triphosphate; Biology; Enzyme; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299503,0.0001496241,0.0003624192,0.0001806985,0.0001880732,0.0006892413,0.0003298237,0.0004605672,0.0008846873],"category_scores_gemma":[0.000769996,0.0002220542,0.0001521698,0.000141742,0.0002741756,0.0006715953,0.0001862636,0.0005095141,0.0002993109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005104958,"about_ca_system_score_gemma":0.0001825023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009955951,"about_ca_topic_score_gemma":0.0007736304,"domain_scores_codex":[0.9996203,0.00006719252,0.00002415471,0.0001077913,0.000115323,0.00006517257],"domain_scores_gemma":[0.9996397,0.0001491022,0.00005515671,0.0000284547,0.00008468448,0.00004278581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096858,0.00002226905,0.001193379,0.00002477832,0.00000540048,0.00003753785,0.00004054476,0.0001308799,0.996472,0.0002106662,0.00002168459,0.001731344],"study_design_scores_gemma":[0.00001295557,0.0002799125,0.04178964,0.00000900396,0.00002188786,0.0003626069,0.0001157959,0.008025985,0.947796,0.0004031249,0.001151969,0.00003100496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935398,0.001253969,0.003768421,0.00006410199,0.00001089183,0.00001467111,0.00006692923,0.00003164982,0.001249665],"genre_scores_gemma":[0.9975621,0.0003706182,0.001222574,0.00002707671,0.000004922244,0.00001798536,0.0001004914,0.00000879759,0.0006855254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009955951,"threshold_uncertainty_score":0.003703952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008933307763677957,"score_gpt":0.214982390287641,"score_spread":0.206049082523963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}