{"id":"W2069219003","doi":"10.1097/01.jnen.0000240470.97295.d3","title":"Upregulated Expression of Purinergic P2X<sub>7</sub>Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus","year":2006,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging","keywords":"Microglia; Purinergic receptor; Hippocampus; Downregulation and upregulation; Peptide; Alzheimer's disease; Amyloid (mycology); Receptor; Chemistry; P3 peptide; Neuroscience; Amyloid β; Amyloid precursor protein; Endocrinology; Internal medicine; Cell biology; Biology; Disease; Medicine; Biochemistry; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264868,0.0002653841,0.0003403937,0.0003414908,0.0001740922,0.0002751183,0.0001039238,0.0002784482,0.00102701],"category_scores_gemma":[0.0001159182,0.0001663987,0.0002108613,0.0001517808,0.0002036354,0.0001898244,0.0001333515,0.0002259248,0.0004255843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737123,"about_ca_system_score_gemma":0.00009472664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003049216,"about_ca_topic_score_gemma":0.0003538425,"domain_scores_codex":[0.9998473,0.0000183533,0.0000159092,0.00002774511,0.00003951334,0.0000511483],"domain_scores_gemma":[0.999902,0.000009774505,0.00003128405,0.00001037226,0.00001893811,0.00002761674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002107773,0.00001555845,0.0006269349,0.0000326262,0.000006599872,0.0003034956,0.00004056224,0.000007679817,0.9980677,0.00002157423,0.00001519747,0.0006513812],"study_design_scores_gemma":[0.00005166087,0.001175613,0.143055,0.00002296647,0.00007837813,0.004558365,0.0002952534,0.0005155572,0.8480608,0.0001521421,0.002018946,0.00001533375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978815,0.001052247,0.0003462849,0.00001777826,0.00001085687,0.000009456444,0.0001329769,0.00001737287,0.0005315072],"genre_scores_gemma":[0.9954723,0.001248091,0.001119837,0.00003773791,0.00002833188,0.0000737992,0.0003640779,0.00001107405,0.001644676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102701,"threshold_uncertainty_score":0.003435731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005928114466319196,"score_gpt":0.2258221981121669,"score_spread":0.2198940836458477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}