{"id":"W2069252726","doi":"10.3987/com-05-s(t)13","title":"From Amino Acids to Polycyclic Heterocycles - Synthesis of Enantiopure, Functionally Diverse Isopavines and Dihydromethanodibenzoazocines","year":2006,"lang":"en","type":"article","venue":"Heterocycles","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Enantiopure drug; Chemistry; Amino acid; Stereochemistry; Organic chemistry; Enantioselective synthesis; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009543336,0.0003908328,0.0006501176,0.0003505005,0.000160533,0.00007381331,0.0003392374,0.0001959812,0.0003505826],"category_scores_gemma":[0.0001677525,0.0003469085,0.0002714294,0.0003186906,0.0001444487,0.0002131004,0.00021752,0.0001023116,0.00005316626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004568699,"about_ca_system_score_gemma":0.00001145021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002540034,"about_ca_topic_score_gemma":0.0002119366,"domain_scores_codex":[0.9978247,0.00003805135,0.0006105629,0.0006525495,0.0004856904,0.0003884132],"domain_scores_gemma":[0.9984111,0.0005861908,0.0002583161,0.0005326191,0.00004953904,0.0001622588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001810274,0.0003620794,0.1672795,0.0001407762,0.0003557265,0.00001770161,0.0001696257,0.00002635882,0.6945968,0.00004556532,0.001143233,0.1356816],"study_design_scores_gemma":[0.0004130655,0.00002772527,0.1472137,0.0001647233,0.0003169994,0.0000126994,0.0005874237,0.00006768923,0.846777,0.0005202994,0.003383328,0.0005152763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994225,0.001550775,0.0002174015,0.0001584656,0.0001014497,0.00007135141,0.0004434709,0.0001084648,0.003123634],"genre_scores_gemma":[0.9975007,0.0001070008,0.001108695,0.000051532,0.000485332,0.00005522517,0.00007721306,0.00005114975,0.0005631125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1521803,"threshold_uncertainty_score":0.9998983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009130947258032714,"score_gpt":0.2146918944814505,"score_spread":0.2055609472234178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}