{"id":"W2069289109","doi":"10.1016/j.chembiol.2004.08.011","title":"High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase","year":2004,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; McMaster University","funders":"","keywords":"Virtual screening; Coronavirus; Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Severe acute respiratory syndrome; Drug discovery; Viral replication; Small molecule; Severe acute respiratory syndrome coronavirus; Förster resonance energy transfer; Virology; IC50; Coronavirus disease 2019 (COVID-19); Sars virus; Computational biology; In vitro; Biochemistry; Virus; Fluorescence; Medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063145,0.0001533586,0.0002809667,0.00002540126,0.00008408273,0.000008797568,0.0002533229,0.0002239958,0.00002716322],"category_scores_gemma":[0.000297301,0.0001072324,0.0001332965,0.0002137002,0.0006165908,0.00002934144,0.0001972652,0.0003243625,0.00001803863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001062661,"about_ca_system_score_gemma":0.0002793822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006260377,"about_ca_topic_score_gemma":0.00001630331,"domain_scores_codex":[0.9988627,0.00003133848,0.000284177,0.0003143843,0.000179346,0.0003280507],"domain_scores_gemma":[0.9992537,0.00004398573,0.0001099398,0.0004746972,0.00008738799,0.00003025831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001831698,0.00007885782,0.008003566,0.0001626594,0.00004521574,0.00004121769,0.00007636941,9.807977e-7,0.9895234,0.00007920391,0.0001282776,0.001677144],"study_design_scores_gemma":[0.001324499,0.00007387127,0.001820817,0.0001385884,0.0000248153,0.00009060154,0.0001250364,0.000001951958,0.9862735,0.001012433,0.009014399,0.00009950341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975249,0.0004702405,0.0001067443,0.0007510095,0.0001177313,0.0003034496,0.00002322468,0.00003699895,0.0006657157],"genre_scores_gemma":[0.9966242,0.000004748328,0.0002564462,0.002671536,0.0002530942,0.0000412129,0.00001271452,0.00001690507,0.0001191295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008886121,"threshold_uncertainty_score":0.4372809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106063172971685,"score_gpt":0.343922753280706,"score_spread":0.3028621215509892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}