{"id":"W2069301738","doi":"10.1038/cgt.2009.28","title":"Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells","year":2009,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Vancouver General Hospital","funders":"Office of Defense Programs; BC Cancer Agency; Terry Fox Foundation","keywords":"LNCaP; Prostate cancer; Trastuzumab; Cancer research; Cytotoxic T cell; Luciferase; Antibody; Antigen; Monoclonal antibody; Virology; Biology; Cell culture; Cancer; Transfection; Immunology; In vitro; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001544475,0.0003354489,0.0002623128,0.00007393785,0.00017069,0.00007994588,0.0002761383,0.00009508167,0.0001039569],"category_scores_gemma":[0.000002709663,0.0002531508,0.000055198,0.0002037045,0.0001310932,0.000008221658,0.00003707398,0.000118741,0.000003034311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000785646,"about_ca_system_score_gemma":0.0004821095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002321144,"about_ca_topic_score_gemma":0.001563777,"domain_scores_codex":[0.9983453,0.00008595716,0.0001770241,0.0006214693,0.000212371,0.0005578563],"domain_scores_gemma":[0.9991894,0.000008033987,0.00006562659,0.0004182149,0.00009738919,0.0002213374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004017761,0.00006622817,0.0009519012,0.000006675999,0.0001567217,0.000003824988,0.0007979794,0.0004514969,0.9040738,0.000001529326,0.001430657,0.08804139],"study_design_scores_gemma":[0.001354091,0.003946044,0.002555582,0.00002116185,0.000007280508,0.000003528329,0.00007050582,0.000006635945,0.9374734,0.00005313359,0.05413432,0.0003743375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740654,0.02282267,0.00006394484,0.001872846,0.0001023349,0.0007212349,0.0002533444,0.00002602752,0.00007223285],"genre_scores_gemma":[0.9650183,0.02857172,0.0002636618,0.004637736,0.0003488566,0.0002668483,0.00003961169,0.00006535235,0.0007878835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08766705,"threshold_uncertainty_score":0.9999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745088884056964,"score_gpt":0.2911360393492196,"score_spread":0.2736851505086499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}