{"id":"W2069308912","doi":"10.1371/journal.pone.0014614","title":"Ablation of Akt2 Induces Autophagy through Cell Cycle Arrest, the Downregulation of p70S6K, and the Deregulation of Mitochondria in MDA-MB231 Cells","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Sudbury Regional Hospital; University of Ottawa","funders":"Cure Brain Cancer Foundation; University of Ottawa","keywords":"AKT2; Protein kinase B; Downregulation and upregulation; Cell biology; PI3K/AKT/mTOR pathway; Autophagy; AKT1; Cancer research; Cell growth; Biology; Mitochondrion; Cell cycle; Cancer cell; Chemistry; Signal transduction; Cell; Cancer; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007868189,0.0004355774,0.000210513,0.0002121959,0.0001977393,0.0002178298,0.0001263714,0.0001678757,0.001013747],"category_scores_gemma":[0.00003868758,0.0001036851,0.0003075366,0.0002215744,0.0001512865,0.0001412962,0.0001159959,0.0004250809,0.0003387065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003450823,"about_ca_system_score_gemma":0.0003679903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001566254,"about_ca_topic_score_gemma":0.002137979,"domain_scores_codex":[0.9999237,0.000004949808,0.000009054553,0.00001525483,0.00002588962,0.00002119423],"domain_scores_gemma":[0.9999657,0.000003286132,0.00001173572,0.000004366565,0.00000501875,0.000009960702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001080621,0.00002499965,0.0002066931,0.00003469455,0.000005137794,0.00003870582,0.000009395689,0.00006329568,0.9988264,0.00006162022,0.00008506601,0.0005358537],"study_design_scores_gemma":[0.00002424013,0.00020873,0.005530642,0.000004126644,0.00002147499,0.0002112154,0.00002445439,0.0009352356,0.9896299,0.00004527866,0.003360148,0.00000465287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916149,0.002523157,0.002005808,0.0001550043,0.0000559968,0.00003108937,0.001392646,0.000171319,0.002050059],"genre_scores_gemma":[0.9920372,0.001515411,0.0017234,0.000076321,0.00001416611,0.00007420991,0.001219534,0.00002685916,0.003312939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566254,"threshold_uncertainty_score":0.003391325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971552869161065,"score_gpt":0.2170722037767116,"score_spread":0.187356675085101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}