{"id":"W2069359359","doi":"10.1039/b818167p","title":"The “metallo-specific” response of proteins: A perspective based on the Escherichia coli transcriptional regulator NikR","year":2009,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Trace Elements in Health","field":"Nursing","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Escherichia coli; Chemistry; Regulator; Metal; Allosteric regulation; Repressor; Transcription factor; Homeostasis; Function (biology); Biophysics; Transcription (linguistics); Gene; Cell biology; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206058,0.0002269318,0.0002114941,0.0001269783,0.001145005,0.00005918831,0.0003430529,0.0001064397,0.0003533534],"category_scores_gemma":[0.000100897,0.0001519834,0.0002347595,0.0005696266,0.0002762805,0.0001326054,0.000001210776,0.0005688854,0.00001969993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000414363,"about_ca_system_score_gemma":0.0001752564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007608497,"about_ca_topic_score_gemma":0.00008538945,"domain_scores_codex":[0.9973486,0.0007874098,0.0004667263,0.0003580781,0.0006360395,0.0004031352],"domain_scores_gemma":[0.9979144,0.0009461451,0.000159637,0.0006798689,0.000199412,0.0001005389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05243593,0.004436951,0.00004999372,0.00007761625,0.0002851061,0.000008833373,0.01501947,0.008791462,0.7792929,0.1130081,0.004992517,0.02160113],"study_design_scores_gemma":[0.009173918,0.01005804,0.2426154,0.0005957402,0.0004712003,0.00002491113,0.01961358,0.01624283,0.3168332,0.01348211,0.3692971,0.001591935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6457756,0.0009576129,0.06828342,0.2729151,0.002410479,0.005842357,0.0005464482,0.0004374479,0.00283155],"genre_scores_gemma":[0.9958593,0.00002448045,0.002229672,0.00117732,0.00009080823,0.0001837887,0.00000479765,0.00003204344,0.0003978137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4624597,"threshold_uncertainty_score":0.8806568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519749015263119,"score_gpt":0.2851061192126976,"score_spread":0.2599086290600665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}