{"id":"W2069385780","doi":"10.1016/j.clml.2011.03.033","title":"Addition of AEG35156 XIAP Antisense Oligonucleotide in Reinduction Chemotherapy Does Not Improve Remission Rates in Patients With Primary Refractory Acute Myeloid Leukemia in a Randomized Phase II Study","year":2011,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Charles-Le Moyne; Université de Montréal; Hôpital Maisonneuve-Rosemont; Aegera Therapeutics (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Idarubicin; Cytarabine; Medicine; Chemotherapy; Myeloid leukemia; Internal medicine; Refractory (planetary science); XIAP; Induction chemotherapy; Gastroenterology; Oncology; Randomized controlled trial; Acute leukemia; Leukemia; Pharmacology; Surgery; Apoptosis; Caspase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001549719,0.001075177,0.003445221,0.0003623751,0.0003393487,0.000832568,0.0009428159,0.0009600958,0.003240174],"category_scores_gemma":[0.00079463,0.0004548311,0.001264923,0.0005349251,0.00119408,0.0008306452,0.0003220141,0.002878967,0.0004603009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008992421,"about_ca_system_score_gemma":0.001025256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116085,"about_ca_topic_score_gemma":0.002960977,"domain_scores_codex":[0.9994656,0.0002475253,0.0000327842,0.00009888638,0.00003748732,0.0001176801],"domain_scores_gemma":[0.9993364,0.0001827592,0.0001341352,0.0001023819,0.00002521852,0.0002190193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.877405,0.01671021,0.002939821,0.0004547094,0.001831524,0.00008103417,0.0001023906,0.001657601,0.02738747,0.0002343064,0.001055755,0.07014018],"study_design_scores_gemma":[0.6646832,0.3180034,0.009882765,0.00003166292,0.001108141,0.0001102342,0.00003719818,0.0007384339,0.004107972,0.0001313919,0.001141968,0.00002369806],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963742,0.001701203,0.0002351037,0.0002126794,0.0001010706,0.0004410463,0.0002648136,0.00004938424,0.0006205151],"genre_scores_gemma":[0.9964652,0.001157736,0.0004464871,0.0002582485,0.00009465686,0.0003599043,0.0004071106,0.00001648445,0.0007940539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003445221,"threshold_uncertainty_score":0.01083946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252439752775815,"score_gpt":0.2751546296371883,"score_spread":0.2626302321094302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}