{"id":"W2069388207","doi":"10.1016/j.bmcl.2011.02.024","title":"Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Enterobacter cloacae; Chemistry; Enzyme; Linker; Ceftazidime; Lactam; Enterobacteriaceae; Stereochemistry; Microbiology; Bacteria; Biochemistry; Escherichia coli; Biology; Pseudomonas aeruginosa; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101436,0.0003855882,0.0003629648,0.0001865618,0.0002118799,0.0004263828,0.0004612199,0.0003351408,0.002328792],"category_scores_gemma":[0.0001372095,0.0002184015,0.0002397394,0.0001722599,0.0001838761,0.0003816243,0.0002615195,0.0006505492,0.0007081584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003548159,"about_ca_system_score_gemma":0.0003284562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004468298,"about_ca_topic_score_gemma":0.001305035,"domain_scores_codex":[0.9999325,0.00001229074,0.00000551701,0.000008789813,0.00001375926,0.00002715873],"domain_scores_gemma":[0.9999608,0.00000483884,0.00000816906,0.000002953656,0.000006145846,0.00001705355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001108307,0.0004255863,0.0003404122,0.0006585688,0.00005430398,0.0006872162,0.0001858542,0.004559128,0.9326176,0.004730458,0.00229226,0.05234035],"study_design_scores_gemma":[0.001482534,0.009497145,0.003018093,0.0001800949,0.0001385767,0.001392115,0.0001122151,0.006705115,0.8716668,0.001399247,0.1043013,0.0001067813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9049836,0.04484611,0.02401891,0.001961726,0.0004983986,0.0005794753,0.001541835,0.0004869103,0.02108307],"genre_scores_gemma":[0.9460213,0.02969645,0.01000986,0.0004693027,0.0001091581,0.0001955675,0.001367761,0.00004130256,0.0120893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002328792,"threshold_uncertainty_score":0.007790565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01296202836964265,"score_gpt":0.2187256589766611,"score_spread":0.2057636306070184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}