{"id":"W2069515129","doi":"10.1021/bi901686j","title":"The Structure of the UbcH8−Ubiquitin Complex Shows a Unique Ubiquitin Interaction Site","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; University of Leeds","keywords":"Ubiquitin; Deubiquitinating enzyme; Ubiquitin ligase; Chemistry; Ubiquitin-conjugating enzyme; Proteolysis; Covalent bond; Active site; Biochemistry; Enzyme; Protein structure; Hydrolase; Ubiquitins; Stereochemistry; Cysteine; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007158326,0.0003299249,0.000342505,0.0002054274,0.0003914909,0.0003876267,0.0003746184,0.0004706866,0.001723224],"category_scores_gemma":[0.0001658171,0.0002334337,0.0001718805,0.0003503197,0.0002652197,0.0002804566,0.0002222773,0.0006755029,0.0003020879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007228047,"about_ca_system_score_gemma":0.0002148363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001589289,"about_ca_topic_score_gemma":0.001550899,"domain_scores_codex":[0.9999096,0.000009029876,0.000003889431,0.00003109135,0.00003127579,0.00001511891],"domain_scores_gemma":[0.999921,0.000009382029,0.00001867107,0.00001050659,0.00001564393,0.00002476408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007302985,0.0001970104,0.007564167,0.0001903777,0.0001278099,0.0009907751,0.0002541789,0.01623913,0.9567008,0.001783884,0.001553569,0.01366804],"study_design_scores_gemma":[0.0002444145,0.001103508,0.130129,0.00005457355,0.0001573864,0.002944935,0.0003814874,0.1474765,0.6777878,0.004049529,0.0355074,0.0001634549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939375,0.0008534219,0.003135909,0.0001608382,0.00001655308,0.000009848945,0.0003928287,0.0001300373,0.001362893],"genre_scores_gemma":[0.9951555,0.000210013,0.002367466,0.00004790689,0.000003579777,0.000009355856,0.0009970047,0.00001544251,0.001193763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723224,"threshold_uncertainty_score":0.005764782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195467871137568,"score_gpt":0.2527241329894847,"score_spread":0.240769454278109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}