{"id":"W2069515129","doi":"10.1021/bi901686j","title":"The Structure of the UbcH8−Ubiquitin Complex Shows a Unique Ubiquitin Interaction Site","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; University of Leeds","keywords":"Ubiquitin; Deubiquitinating enzyme; Ubiquitin ligase; Chemistry; Ubiquitin-conjugating enzyme; Proteolysis; Covalent bond; Active site; Biochemistry; Enzyme; Protein structure; Hydrolase; Ubiquitins; Stereochemistry; Cysteine; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539271,0.0002184917,0.000150026,0.0000123844,0.0002330162,0.00004538971,0.0005140013,0.0002401246,0.00008395822],"category_scores_gemma":[0.0001549554,0.0001429882,0.0001771377,0.0001134347,0.0001742901,0.000003919944,0.0001585728,0.0002371291,0.000003245544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002688014,"about_ca_system_score_gemma":0.0001067491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000109636,"about_ca_topic_score_gemma":0.0000311163,"domain_scores_codex":[0.9987919,0.00009060167,0.0003083104,0.0003257458,0.0001938077,0.0002896836],"domain_scores_gemma":[0.9988121,0.00002796188,0.0002349472,0.0007255557,0.0001266551,0.00007282129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009176754,0.00003046038,0.0002460943,0.00002550509,0.00002153048,7.412933e-7,0.0000531449,0.000006999093,0.9918839,0.0001311579,0.004699087,0.002809606],"study_design_scores_gemma":[0.000248674,0.00009826087,0.0008892924,0.0000400942,0.00001519446,0.00004215142,0.0001417284,0.00004173921,0.9687394,0.0002570799,0.0293135,0.0001728742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943139,0.0004359556,0.00006487257,0.0008979565,0.0001383788,0.0002468416,0.0001604728,0.00002034612,0.00372129],"genre_scores_gemma":[0.9971142,0.00005688193,0.0002088195,0.0007064507,0.0003892494,0.000006447241,0.0001650063,0.00001739646,0.001335565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02461441,"threshold_uncertainty_score":0.5830888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195467871137568,"score_gpt":0.2527241329894847,"score_spread":0.240769454278109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}