{"id":"W2069526468","doi":"10.1210/me.2002-0149","title":"Pax-2 Activates the Proglucagon Gene Promoter But Is Not Essential for Proglucagon Gene Expression or Development of Proglucagon-Producing Cell Lineages in the Murine Pancreas or Intestine","year":2002,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto","keywords":"Proglucagon; Biology; Enteroendocrine cell; Pancreas; Molecular biology; Gene expression; Islet; Prohormone convertase; Cell biology; Gene; Endocrinology; Glucagon-like peptide-1; Endocrine system; Prohormone; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283338,0.0004206987,0.0001624638,0.0003017914,0.0001646497,0.0003402549,0.0002291186,0.0002655618,0.001953006],"category_scores_gemma":[0.0001580257,0.0003130101,0.0002216221,0.0001289121,0.00030143,0.0002744016,0.0003098779,0.0005247909,0.0006237253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263273,"about_ca_system_score_gemma":0.0002470769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003722175,"about_ca_topic_score_gemma":0.000763857,"domain_scores_codex":[0.9997963,0.00003303798,0.0000186545,0.00005533818,0.00005052631,0.00004602456],"domain_scores_gemma":[0.9997235,0.00006047689,0.00008006462,0.000043775,0.00001177893,0.00008039279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003393066,0.000006199349,0.0001900052,0.00001071314,0.000001548409,0.0000475592,0.000006419867,0.00002426773,0.9993238,0.00008053504,0.00001074048,0.0002642431],"study_design_scores_gemma":[0.00002991696,0.000161164,0.006955709,0.00001099071,0.00001081596,0.00048645,0.00002452285,0.0006914766,0.9885426,0.00006654556,0.003015954,0.000003886545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936222,0.000881616,0.003015818,0.00008432552,0.00002164287,0.00001980224,0.0004366774,0.0001085855,0.001809199],"genre_scores_gemma":[0.9912468,0.0004920863,0.002981958,0.00005483249,0.00001127104,0.00005923656,0.0009995161,0.00006163248,0.004092749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953006,"threshold_uncertainty_score":0.006533444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04093938816295617,"score_gpt":0.2834529731874222,"score_spread":0.2425135850244661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}