{"id":"W2069548171","doi":"10.1200/jco.2010.30.1986","title":"The Curse of Dimensionality: A Blessing to Personalized Medicine","year":2010,"lang":"en","type":"letter","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Blessing; Medicine; Curse; Personalized medicine; Curse of dimensionality; Traditional medicine; Family medicine; Bioinformatics; Artificial intelligence; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01122234,0.000785371,0.002835815,0.001198379,0.003169793,0.005273097,0.002079796,0.01979204,0.005849958],"category_scores_gemma":[0.0747553,0.0005628711,0.001217832,0.001053594,0.0115383,0.009682568,0.00280946,0.03768752,0.002712089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003163059,"about_ca_system_score_gemma":0.002659769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001803515,"about_ca_topic_score_gemma":0.003116895,"domain_scores_codex":[0.9901969,0.005763538,0.0007783162,0.0007361886,0.002261042,0.0002639402],"domain_scores_gemma":[0.920237,0.06782664,0.001421177,0.002465568,0.005758783,0.002290936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001060335,0.00004043609,0.0007567361,0.0002714734,0.00009920084,0.001154698,0.000430333,0.0003815835,0.0001756765,0.03232186,0.9114885,0.05277359],"study_design_scores_gemma":[0.0003211333,0.0001034029,0.0009072397,0.0008353178,0.00009264025,0.005215805,0.00108735,0.003225842,0.0003112026,0.4481094,0.5396243,0.0001663398],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002357855,0.005908838,0.001090838,0.9842728,0.007488762,0.000004659759,0.00003074265,0.00001873279,0.0009487719],"genre_scores_gemma":[0.01602141,0.01471892,0.004546107,0.8499625,0.1126686,0.00007303037,0.00004190835,0.00005589423,0.001911719],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01979204,"threshold_uncertainty_score":0.05935013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1081063031593174,"score_gpt":0.4830861910807145,"score_spread":0.3749798879213972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}