{"id":"W2069558973","doi":"10.1096/fj.05-5495com","title":"Proteasome inhibition induces reversible impairments in protein synthesis","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Abercrombie Foundation","keywords":"Proteasome; Neurotoxicity; Proteasome inhibitor; Protein biosynthesis; Neuron; Cell biology; Biology; Chemistry; Biochemistry; Neuroscience; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006558855,0.0001213124,0.0001004335,0.00006638309,0.0001730486,0.00005585104,0.0001649734,0.00009835593,0.0000715948],"category_scores_gemma":[0.00006609896,0.00008671053,0.00007661701,0.0001127884,0.00005540009,0.00001040953,0.00006024199,0.0002287312,0.00002524793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003552875,"about_ca_system_score_gemma":0.00008759508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006069647,"about_ca_topic_score_gemma":0.00002469577,"domain_scores_codex":[0.9989952,0.0001980894,0.000221768,0.0001523525,0.0001713807,0.0002612275],"domain_scores_gemma":[0.9995973,0.000009016744,0.0001312323,0.0001689754,0.00004274636,0.00005078158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007621596,0.00007694018,0.0009574606,0.00001034829,0.00001063723,0.00003561904,0.00003336203,0.00001992674,0.9973446,0.00003605328,0.0005369733,0.0008618786],"study_design_scores_gemma":[0.0004077878,0.0001381099,0.00197564,0.00009332458,0.0000072606,0.0002790974,0.00009379553,0.000006131777,0.9950785,0.001096762,0.0007005382,0.0001230189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996889,0.0002810283,0.00008407357,0.0004068984,0.00005348722,0.0004151243,0.00001117803,0.000007586455,0.001851655],"genre_scores_gemma":[0.9983646,0.00002494083,0.00029627,0.00008466902,0.000431356,0.00008304408,0.00001173624,0.00001466799,0.000688677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266051,"threshold_uncertainty_score":0.3535953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194188475145482,"score_gpt":0.2247070768628022,"score_spread":0.2127651921113473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}