{"id":"W2069568833","doi":"10.1615/critrevimmunol.v23.i56.40","title":"A Cell Death Pathway Induced by Antibody-Mediated Cross-Linking of CD45 on Lymphocytes","year":2003,"lang":"en","type":"review","venue":"Critical Reviews in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Université de Montréal; BioPhage Pharma (Canada)","funders":"","keywords":"Dephosphorylation; Cell biology; Programmed cell death; Protein tyrosine phosphatase; Signal transduction; Jurkat cells; Biology; Phosphorylation; Receptor; Phosphatase; T cell; Apoptosis; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001743271,0.001544546,0.007515677,0.0008247241,0.00025741,0.00004087117,0.001686523,0.004319098,0.00118279],"category_scores_gemma":[0.003135597,0.001243585,0.001332804,0.0009245791,0.001766772,0.0001276973,0.0004691733,0.003325025,0.004738418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668945,"about_ca_system_score_gemma":0.000879931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007341333,"about_ca_topic_score_gemma":0.000004132739,"domain_scores_codex":[0.9876674,0.004541083,0.003992692,0.001625917,0.0001142837,0.00205857],"domain_scores_gemma":[0.9924818,0.004318507,0.001173357,0.001731885,0.0002093623,0.00008512691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001846043,0.002654886,0.00004618684,0.02003218,0.0006298131,0.0001180227,0.0001223079,8.212299e-8,0.5439528,0.00989391,0.001204676,0.4211605],"study_design_scores_gemma":[0.001834359,0.0009218209,0.000003520867,0.0139086,0.0003967384,0.000242058,0.00001887446,1.731965e-7,0.01288819,0.0002283111,0.9685326,0.001024735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00199617,0.989476,0.00002591401,0.0000251343,0.003171142,0.001680478,0.0002575534,0.00009433318,0.003273282],"genre_scores_gemma":[0.00232361,0.9935767,0.00008572244,0.0002774774,0.00004446784,0.0004180092,0.001802226,0.0001621179,0.001309659],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.967328,"threshold_uncertainty_score":0.9997303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05249385967425513,"score_gpt":0.3557980711605897,"score_spread":0.3033042114863346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}