{"id":"W2069571430","doi":"10.1038/nmeth.2729","title":"Parallel measurement of dynamic changes in translation rates in single cells","year":2013,"lang":"en","type":"article","venue":"Nature Methods","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Translation (biology); Translational regulation; Protein biosynthesis; Computational biology; Biology; Messenger RNA; Amino acid; Cell biology; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009639873,0.00009711388,0.0001485926,0.00007536275,0.000008874936,0.000006538337,0.0001039039,0.000328817,0.00003137044],"category_scores_gemma":[0.00009325636,0.00008584239,0.00003807996,0.0001051399,0.00001581594,0.000002984516,0.00001454086,0.0001235119,0.000001431448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001768237,"about_ca_system_score_gemma":0.00001770266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000334446,"about_ca_topic_score_gemma":0.0003583855,"domain_scores_codex":[0.9990334,0.000360971,0.0001604027,0.0001914069,0.0001158163,0.0001380053],"domain_scores_gemma":[0.999669,0.00002945979,0.00005986772,0.0001625603,0.0000572564,0.00002185734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002382245,0.00004129756,0.00007331415,0.00002092021,0.000006409999,2.696223e-7,0.00004344677,0.00002014591,0.8753783,0.00001225741,0.00001423104,0.1243656],"study_design_scores_gemma":[0.00028204,0.0001054083,0.001859491,0.00003119918,0.00000395646,5.004344e-7,0.00003326261,0.0001648203,0.9950221,0.0009399836,0.001462615,0.00009465643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8483093,0.02263006,0.1245051,0.001185016,0.0004811013,0.001305992,0.00000736717,0.00001350766,0.001562566],"genre_scores_gemma":[0.7636102,0.000134788,0.2360609,0.00006634597,0.00001912479,0.00004745672,0.000006531584,0.000009737209,0.00004488866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.124271,"threshold_uncertainty_score":0.3500551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02905289300817065,"score_gpt":0.324744373843711,"score_spread":0.2956914808355404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}