{"id":"W2069579434","doi":"10.1016/j.atherosclerosis.2008.07.029","title":"IFN-γ down-regulates ABCA1 expression by inhibiting LXRα in a JAK/STAT signaling pathway-dependent manner","year":2008,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"stat; JAK-STAT signaling pathway; ABCA1; Signal transduction; Cell biology; Janus kinase; Cancer research; Chemistry; Biology; STAT3; Biochemistry; Gene; Receptor tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003459909,0.0003589626,0.0005758269,0.0001627779,0.0002029603,0.00004020592,0.0001527657,0.0002221165,0.0001715364],"category_scores_gemma":[0.00006861339,0.0002990163,0.0001814224,0.000292092,0.0001052855,0.000241411,0.0001184869,0.0004079777,0.00009137367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001013333,"about_ca_system_score_gemma":0.00005349203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002913825,"about_ca_topic_score_gemma":0.00001747658,"domain_scores_codex":[0.9975397,0.00009910951,0.0006073449,0.0006007496,0.0005401656,0.0006129089],"domain_scores_gemma":[0.9990273,0.00009102213,0.0001742451,0.0003815564,0.00006973454,0.0002562021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008975495,0.0003169858,0.03085101,0.00005409126,0.0000210884,0.00002244015,0.002855844,0.00004362134,0.9613587,0.00001049379,0.00195256,0.002423394],"study_design_scores_gemma":[0.004913244,0.0001273119,0.06868196,0.001059004,0.00005031293,0.00005527708,0.0006264789,0.0001707619,0.9202748,0.00004865764,0.003541949,0.0004502716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971793,0.001029672,0.00008679987,0.000400954,0.0002218676,0.0004368069,0.00003136055,0.0002164459,0.0003968035],"genre_scores_gemma":[0.9961747,0.0002697263,0.0005380957,0.0008555888,0.0003415206,0.00007946248,0.00004274776,0.0001063041,0.001591859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04108395,"threshold_uncertainty_score":0.9999462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400479324886014,"score_gpt":0.2338003458181315,"score_spread":0.2097955525692714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}