{"id":"W2069729429","doi":"10.1074/jbc.m301162200","title":"Roles of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood properties and coagulation","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Enzyme; Chemistry; Tissue transglutaminase; Binding site; Active site; Enzyme assay; Tryptophan; Enzyme activator; Lanthanide; Ion; Stereochemistry; Biophysics; Biochemistry; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002566669,0.00004160387,0.0001387555,0.000007347543,0.00001667087,0.000001839205,0.00004921829,0.00007590478,0.00001957321],"category_scores_gemma":[0.0001882334,0.00001687736,0.00006291006,0.00007083349,0.00008168383,0.0000206842,0.000005638833,0.000172833,2.036058e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008925424,"about_ca_system_score_gemma":0.00003091629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003406001,"about_ca_topic_score_gemma":5.066869e-7,"domain_scores_codex":[0.9995828,0.00005639118,0.0001762407,0.00003928465,0.00009784981,0.00004746683],"domain_scores_gemma":[0.99964,0.00007107827,0.0001570121,0.00006720556,0.00004670646,0.00001792715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001498746,0.0001591465,0.01276119,0.00003757784,0.00001137987,0.000001054524,0.0001349168,0.000007999543,0.9851765,0.00001644181,0.00001027021,0.00153364],"study_design_scores_gemma":[0.0003922492,0.0001122177,0.1383148,0.00006265334,0.00002172985,0.00005795353,0.0003288134,0.00001625173,0.8604411,0.0001019543,0.0001325085,0.00001775234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998295,0.0002545104,0.00007881604,0.0009484222,0.000008550862,0.00004599528,0.000001330537,6.763937e-7,0.0003666992],"genre_scores_gemma":[0.9998307,0.00004058379,0.00003407877,0.00005100971,0.00002662125,6.925899e-7,2.863302e-7,0.00000121663,0.00001485557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1255537,"threshold_uncertainty_score":0.07508828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0436867989130483,"score_gpt":0.2676931293468127,"score_spread":0.2240063304337644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}