{"id":"W2069770612","doi":"10.1016/j.molmed.2014.12.004","title":"Nongenetic inheritance and transgenerational epigenetics","year":2014,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Transgenerational epigenetics; Epigenome; Epigenetics; Inheritance (genetic algorithm); Biology; Germline; Phenotype; Genetics; Heredity; Epigenesis; Mechanism (biology); Disease; Evolutionary biology; DNA methylation; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004306446,0.0004875817,0.001062155,0.0003401366,0.00004442863,0.00001548343,0.0002458338,0.0005106095,0.00005124916],"category_scores_gemma":[0.00008696042,0.0004264433,0.0001730136,0.0003609169,0.0002085445,0.000001500175,0.00007105515,0.0002490791,0.000004063157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002456938,"about_ca_system_score_gemma":0.00007580395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009265485,"about_ca_topic_score_gemma":0.00006019213,"domain_scores_codex":[0.9976361,0.0002877963,0.0007442313,0.0007332604,0.0002783542,0.0003202859],"domain_scores_gemma":[0.9990075,0.00003259355,0.0002123907,0.0005462599,0.00005484539,0.0001464142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004840796,0.00002534053,0.00002147137,0.0009342902,0.00006183643,0.00001337981,0.00002313678,0.00004145953,0.004480694,0.0001107645,0.00009192852,0.9941909],"study_design_scores_gemma":[0.0005775458,0.0003790756,0.0001037832,0.001357157,0.0002667548,0.00001632773,0.000003105885,0.00004186841,0.0008449794,0.0001215065,0.9958274,0.0004604683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005049773,0.9909475,0.006676597,0.00008806915,0.0002116198,0.0002277672,0.00001725156,0.000008725051,0.001317437],"genre_scores_gemma":[0.001058369,0.994265,0.002381367,0.000100272,0.0005070072,0.00007913569,0.001014488,0.00008937592,0.0005050012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9957355,"threshold_uncertainty_score":0.9998187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406404326250979,"score_gpt":0.3536463195931679,"score_spread":0.3195822763306582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}