{"id":"W2069793776","doi":"10.1007/s00044-010-9307-4","title":"Modification and biological evaluation of novel 4-hydroxy-pyrone derivatives as non-peptidic HIV-1 protease inhibitors","year":2010,"lang":"en","type":"article","venue":"Medicinal Chemistry Research","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Natural Science Foundation of China","keywords":"Chemistry; IC50; Protease; Stereochemistry; HIV-1 protease; Pyrone; EC50; Enzyme; Western blot; Human immunodeficiency virus (HIV); Binding affinities; Biochemistry; In vitro; Virology; Biology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002745959,0.0001576457,0.000270213,0.0001174535,0.0001240874,0.00001169312,0.000105412,0.0001771407,0.0004990303],"category_scores_gemma":[0.001853428,0.0001143613,0.00003850682,0.0003417436,0.0006391005,0.00005263166,0.00007783058,0.0006198313,0.00002836771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001103024,"about_ca_system_score_gemma":0.0005833778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002880001,"about_ca_topic_score_gemma":0.000001224818,"domain_scores_codex":[0.9974363,0.00006887772,0.000319448,0.0003947563,0.001472988,0.0003075751],"domain_scores_gemma":[0.9984416,0.0001528762,0.00008468493,0.0002995627,0.0007365617,0.0002847211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002250476,0.000566624,0.02517402,0.0001961602,0.00005187642,0.00001243737,0.0007207373,6.13003e-7,0.968049,0.00002143321,0.0006478681,0.004334211],"study_design_scores_gemma":[0.004740673,0.0002423149,0.02775318,0.0002997924,0.00008199793,0.0001005903,0.001158756,0.002728962,0.9616986,0.0001864225,0.0008682397,0.0001404714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892755,0.0001586343,0.00004596344,0.004018309,0.00002554322,0.0009565385,0.000006347235,0.00002008818,0.005493138],"genre_scores_gemma":[0.9959271,0.00004309767,0.0007948711,0.00001413955,0.000225228,0.0002664315,0.0001583937,0.00001334027,0.002557396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006651664,"threshold_uncertainty_score":0.5464032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1307808618470524,"score_gpt":0.4178142084991379,"score_spread":0.2870333466520855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}