{"id":"W2069838467","doi":"10.1517/13543784.12.1.65","title":"Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the future","year":2003,"lang":"en","type":"review","venue":"Expert Opinion on Investigational Drugs","topic":"Treatment of Major Depression","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"","keywords":"Monoaminergic; Major depressive disorder; Tricyclic; Neuroscience; Psychology; Antidepressant; Monoamine neurotransmitter; Medicine; Psychiatry; Pharmacology; Psychotherapist; Serotonin; Mood; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003962032,0.0003723323,0.000661785,0.0001352875,0.0001953898,0.00002157449,0.0001395639,0.0002207923,0.00000951996],"category_scores_gemma":[0.00006093703,0.0001829439,0.0001009179,0.0001775117,0.0001845881,0.00004843375,0.00002991783,0.000238074,6.486597e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009626638,"about_ca_system_score_gemma":0.0002032564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000351923,"about_ca_topic_score_gemma":2.727841e-7,"domain_scores_codex":[0.9983091,0.0002060691,0.0005184914,0.000480707,0.0002976687,0.0001880104],"domain_scores_gemma":[0.9983848,0.0008976349,0.0003505392,0.0002438529,0.00004217124,0.00008095589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008590535,0.0002498098,0.0001650044,0.0006219085,0.0002266654,6.119211e-7,0.0009942347,0.000003240012,0.00001218236,0.0009023104,0.00107608,0.995662],"study_design_scores_gemma":[0.002664976,0.0001107464,0.0005706851,0.00555962,0.00007347538,0.00009069655,0.0002740167,0.0000511102,0.00003768879,0.0001068667,0.9902906,0.0001694825],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001117058,0.9954171,0.0000583853,0.001391268,0.0004401034,0.002177012,0.00003981254,0.00001162866,0.0003530359],"genre_scores_gemma":[0.00004513701,0.9877639,0.009513705,0.0008315427,0.0003206083,0.0009398339,0.0004835941,0.00003803352,0.00006359475],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9954926,"threshold_uncertainty_score":0.7460235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2784800403397673,"score_gpt":0.4347821196305606,"score_spread":0.1563020792907933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}