{"id":"W2069863598","doi":"10.1016/j.scr.2013.10.003","title":"Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells","year":2013,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; L'Oreal USA; Stem Cell Network; Health Canada; Canadian Diabetes Association; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Heart and Stroke Foundation of Canada","keywords":"Biology; Internal medicine; PDX1; Endocrinology; GLUT1; Glucose transporter; Glucokinase; Population; Pinacidil; Islet; Molecular biology; Insulin; Glibenclamide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007395247,0.000161772,0.0004306027,0.0004407314,0.00009722802,0.00004512832,0.0001685006,0.0001382342,0.0007159394],"category_scores_gemma":[0.00001511275,0.0001449362,0.0000737829,0.0005401906,0.0001116323,0.0001436226,0.0001067117,0.0004438757,0.0005359982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001593722,"about_ca_system_score_gemma":0.0002123291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008159424,"about_ca_topic_score_gemma":0.000004992934,"domain_scores_codex":[0.9975092,0.0002936679,0.0004847753,0.0004511239,0.000740865,0.0005204029],"domain_scores_gemma":[0.9985186,0.0002694373,0.0001215754,0.0005120681,0.000361417,0.0002168865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001991394,0.0002156161,0.001593716,0.0001973225,0.00002177057,0.000007635241,0.0006422845,0.000001666665,0.99279,0.000006477122,0.0002149645,0.004109334],"study_design_scores_gemma":[0.001414953,0.0002049106,0.03637255,0.0001304838,0.00001356545,4.577553e-7,0.0006671328,0.0004606865,0.9603742,0.00002179633,0.0002277661,0.0001115237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949703,0.0003043581,0.00002263428,0.0001742545,0.0001475293,0.0008913259,0.0000308093,0.0000322592,0.003426548],"genre_scores_gemma":[0.9914162,0.00008878649,0.0001216331,0.00006314485,0.0001514902,0.00006769109,0.0001007559,0.00003358648,0.00795676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03477884,"threshold_uncertainty_score":0.7839034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04820068759555107,"score_gpt":0.2985444211697544,"score_spread":0.2503437335742033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}