{"id":"W2069863598","doi":"10.1016/j.scr.2013.10.003","title":"Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells","year":2013,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; L'Oreal USA; Stem Cell Network; Health Canada; Canadian Diabetes Association; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Heart and Stroke Foundation of Canada","keywords":"Biology; Internal medicine; PDX1; Endocrinology; GLUT1; Glucose transporter; Glucokinase; Population; Pinacidil; Islet; Molecular biology; Insulin; Glibenclamide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164066,0.000241216,0.0003238744,0.0002731911,0.0001207259,0.0004858919,0.000195499,0.0001900241,0.001342924],"category_scores_gemma":[0.0001957473,0.0001541883,0.0002191625,0.000391218,0.0001047783,0.0001330932,0.0002337194,0.0004111283,0.001064182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001120986,"about_ca_system_score_gemma":0.000133765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003698919,"about_ca_topic_score_gemma":0.0005270452,"domain_scores_codex":[0.9998202,0.00001405398,0.00003996422,0.00003921674,0.00006874599,0.00001783425],"domain_scores_gemma":[0.9998047,0.00005110526,0.00002149121,0.00003556305,0.00005136079,0.00003585062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000073152,0.000025542,0.001190125,0.00008774625,0.000008164678,0.0002235761,0.00008637962,0.0001209847,0.9948608,0.0001353848,0.00009523984,0.003092846],"study_design_scores_gemma":[0.00002245127,0.0002801795,0.02956074,0.00003957222,0.00006193724,0.0007791624,0.0001149884,0.001776983,0.9471887,0.0001118174,0.02005012,0.0000133016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456068,0.005909387,0.02870238,0.0001634547,0.0001773682,0.0007653704,0.007151161,0.0002018747,0.0113222],"genre_scores_gemma":[0.9387034,0.005069263,0.02296372,0.0002955106,0.00007152571,0.0006403209,0.02000067,0.0001282519,0.01212736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342924,"threshold_uncertainty_score":0.004492521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04820068759555107,"score_gpt":0.2985444211697544,"score_spread":0.2503437335742033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}