{"id":"W2069869101","doi":"10.1371/journal.pone.0008555","title":"A Strategy for Eliciting Antibodies against Cryptic, Conserved, Conformationally Dependent Epitopes of HIV Envelope Glycoprotein","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Center for AIDS Research, University of Washington; U.S. Public Health Service; National Institutes of Health; York University","keywords":"Epitope; Antibody; Glycoprotein; Biology; Virology; Antiserum; Antigen; Antibody Repertoire; Molecular biology; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002504104,0.0005866407,0.0001815306,0.0002551796,0.0001412169,0.0002399157,0.0004117111,0.0006107681,0.0006392045],"category_scores_gemma":[0.0001138646,0.0001623554,0.0002751104,0.0001187705,0.0003402159,0.0002769544,0.0002828589,0.001030831,0.0001914705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162159,"about_ca_system_score_gemma":0.0002357909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227924,"about_ca_topic_score_gemma":0.0004033522,"domain_scores_codex":[0.9998569,0.00002191548,0.00001144252,0.00003742346,0.0000412271,0.00003097219],"domain_scores_gemma":[0.999896,0.00002048473,0.0000328349,0.00001684604,0.00001246326,0.00002133199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004402817,0.00009898878,0.0001408916,0.00005932446,0.000006560844,0.00003899274,0.000009091647,0.00008229585,0.9962627,0.0001649734,0.00003732124,0.003054834],"study_design_scores_gemma":[0.00007412193,0.002005816,0.001391877,0.00001379807,0.00004713,0.0009074904,0.00001077607,0.000752684,0.991622,0.0001514063,0.003017283,0.000005732855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396468,0.002294019,0.0549066,0.0004293935,0.00007345062,0.0003574379,0.0002218992,0.0002305818,0.001839857],"genre_scores_gemma":[0.932117,0.001736968,0.06343997,0.0003167008,0.00003006832,0.0001958779,0.000314396,0.00002207444,0.001826923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006392045,"threshold_uncertainty_score":0.002294302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04497519586206547,"score_gpt":0.2643697555960547,"score_spread":0.2193945597339893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}