{"id":"W2069894530","doi":"10.1111/j.1365-2249.2008.03690.x","title":"Essential role of toxin A in <i>C. difficile</i> 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function","year":2008,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Clostridium difficile toxin A; Toxin; Clostridium difficile toxin B; Caco-2; Sepharose; Microbiology; Monoclonal antibody; Barrier function; Epithelium; Clostridium difficile; Antibody; Biology; Chemistry; Molecular biology; Immunology; In vitro; Biochemistry; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089945,0.0002042459,0.0006918425,0.0001744097,0.00005278024,0.000004458136,0.0001438917,0.0003083877,0.0004115498],"category_scores_gemma":[0.0005528547,0.0001865215,0.0001383063,0.0002312006,0.001164698,0.00007688204,0.0001949062,0.0006059766,0.0000201847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007448282,"about_ca_system_score_gemma":0.0002106356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005778825,"about_ca_topic_score_gemma":0.00003247709,"domain_scores_codex":[0.9976296,0.000219673,0.001066182,0.0004357633,0.0002989546,0.0003497873],"domain_scores_gemma":[0.998854,0.0003825024,0.0001818796,0.0003145044,0.0001292739,0.0001378347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004543054,0.001729253,0.02601889,0.00002392336,0.00008626456,0.00006779789,0.0003515535,7.891551e-7,0.9646294,0.0001843344,0.00001801292,0.002346699],"study_design_scores_gemma":[0.005246617,0.00441372,0.136517,0.0001082097,0.00004574289,0.0001949612,0.001855168,0.0001834884,0.8510498,0.00002364866,0.0002005577,0.0001610291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959844,0.002913748,0.00001360147,0.00007359948,0.0001815308,0.0003493436,0.0001151878,0.00002417242,0.0003444249],"genre_scores_gemma":[0.9984862,0.001027695,0.00007977876,0.00004162812,0.0001086821,0.0000263056,0.0001391871,0.00002120888,0.00006927383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1135796,"threshold_uncertainty_score":0.7606127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0418629883906667,"score_gpt":0.3521646685685423,"score_spread":0.3103016801778756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}