{"id":"W2069894530","doi":"10.1111/j.1365-2249.2008.03690.x","title":"Essential role of toxin A in <i>C. difficile</i> 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function","year":2008,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Clostridium difficile toxin A; Toxin; Clostridium difficile toxin B; Caco-2; Sepharose; Microbiology; Monoclonal antibody; Barrier function; Epithelium; Clostridium difficile; Antibody; Biology; Chemistry; Molecular biology; Immunology; In vitro; Biochemistry; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388294,0.000252905,0.0002135806,0.0002013971,0.0001522583,0.0004173498,0.0002518724,0.0004040304,0.000775432],"category_scores_gemma":[0.0003290743,0.0001405235,0.0003785685,0.0001996849,0.0002241106,0.0001839925,0.0002373131,0.0004993122,0.0003705775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003210969,"about_ca_system_score_gemma":0.0003542914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001627527,"about_ca_topic_score_gemma":0.001360124,"domain_scores_codex":[0.9996717,0.00007928154,0.00004149389,0.00003901107,0.0001049988,0.00006353353],"domain_scores_gemma":[0.9997028,0.00006721665,0.00005992574,0.00003871666,0.00007260808,0.00005882006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001178436,0.00003661984,0.0003780501,0.00002548649,0.000003908666,0.00003531588,0.00001009676,0.00001750116,0.9989972,0.00002955356,0.00001405469,0.00033444],"study_design_scores_gemma":[0.00002047031,0.0006457331,0.02934748,0.00001346593,0.00002813229,0.000513733,0.00008048703,0.0007197448,0.9673121,0.00003533483,0.001275406,0.000007836941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978174,0.0006945615,0.0005695476,0.00004665832,0.00001061181,0.00001230019,0.0002138486,0.0000174648,0.00061762],"genre_scores_gemma":[0.9967025,0.0002989678,0.001335283,0.00005738555,0.000004620265,0.00001634686,0.00089754,0.00001311639,0.0006742745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001627527,"threshold_uncertainty_score":0.003236055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0418629883906667,"score_gpt":0.3521646685685423,"score_spread":0.3103016801778756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}