{"id":"W2069902808","doi":"10.1038/onc.2011.127","title":"Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research","keywords":"Transcription factor; Biology; SMAD; Gene silencing; Gene knockdown; Cell biology; Cancer research; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125081,0.00010432,0.000112883,0.00004374147,0.00003500595,0.000007210603,0.00007034177,0.00007727786,0.00001819839],"category_scores_gemma":[0.000008577743,0.00007977791,0.00003386618,0.00008474672,0.00003796492,0.00001163205,0.000008917286,0.00004480053,8.311788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081891,"about_ca_system_score_gemma":0.00003110828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002763474,"about_ca_topic_score_gemma":0.001998002,"domain_scores_codex":[0.9993819,0.00005008456,0.0001440091,0.0002296567,0.00007654815,0.00011781],"domain_scores_gemma":[0.9996766,0.000008878389,0.00007658968,0.0001348236,0.00006558226,0.00003755302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009158883,0.00005461691,0.0002014689,0.00002871785,0.00002867518,3.011585e-7,0.0003858089,0.0003235529,0.9953591,0.00004737185,0.00001449141,0.002639994],"study_design_scores_gemma":[0.0004887109,0.0003207769,0.01848114,0.00003420289,0.00003035122,0.000001715455,0.00003828052,0.0002279959,0.9795786,0.00002027463,0.0006775328,0.0001004691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904573,0.0001346086,0.008607064,0.0001464522,0.0001714359,0.0003358376,0.00003429967,0.000004457516,0.0001085384],"genre_scores_gemma":[0.9991292,0.0000633082,0.0004392177,0.00003416692,0.00005880561,0.00006579919,0.00001687177,0.00001354009,0.0001791132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01827967,"threshold_uncertainty_score":0.3253249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252871116199069,"score_gpt":0.2598102754979887,"score_spread":0.2345231638780818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}