{"id":"W2069916598","doi":"10.1007/s00424-006-0202-2","title":"Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel","year":2007,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences","keywords":"Batrachotoxin; Residue (chemistry); Serine; Anesthetic; Sodium channel; Chemistry; Anesthetic Effect; Pharmacology; Biophysics; Anesthesia; Medicine; Biochemistry; Biology; Sodium; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001310957,0.0001386549,0.0001850723,0.0001188111,0.0001078792,0.00001608973,0.0001597053,0.00004285349,0.000005389445],"category_scores_gemma":[0.00004510325,0.0001027791,0.0001115768,0.00008403732,0.0002122115,0.000007167393,0.00005419812,0.0002459073,0.00000558434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009063507,"about_ca_system_score_gemma":0.00002283156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001034862,"about_ca_topic_score_gemma":0.000006192179,"domain_scores_codex":[0.9984857,0.0005973286,0.0003640841,0.0001926066,0.0001189077,0.0002413165],"domain_scores_gemma":[0.9994417,0.00003982203,0.0001959352,0.0001735378,0.00006495878,0.00008397461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004009402,0.000051901,0.0001483256,0.00001361239,0.00003601248,0.0001123871,0.0008736835,0.0005863059,0.9877318,0.0001366511,0.0006058168,0.00930261],"study_design_scores_gemma":[0.005443374,0.006580334,0.6333294,0.0001932645,0.0001225095,0.004368265,0.00920322,0.000886225,0.2781018,0.002766634,0.0578892,0.001115777],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942923,0.0002157264,0.002950583,0.0002552108,0.0002598098,0.00008797921,0.000001430102,0.000003776286,0.001933206],"genre_scores_gemma":[0.9983706,0.00009753245,0.0001449288,0.0004621411,0.0008090865,2.643491e-7,0.00001758342,0.00002211637,0.00007573086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.70963,"threshold_uncertainty_score":0.4191208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067515845765308,"score_gpt":0.2419285911529674,"score_spread":0.2312534326953144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}