{"id":"W2069973493","doi":"10.1371/journal.pone.0038796","title":"Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"MAPK/ERK pathway; Guanine nucleotide exchange factor; Biology; Cell biology; Function (biology); Signal transduction; Phenotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009568242,0.0003003642,0.0001438561,0.0001892719,0.0001828181,0.0002905193,0.0001937208,0.0001850789,0.0007117768],"category_scores_gemma":[0.00008660628,0.0000985894,0.0001910792,0.0001232236,0.0002568886,0.0002282051,0.0002953452,0.000494694,0.0003493503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416283,"about_ca_system_score_gemma":0.0001266887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001887867,"about_ca_topic_score_gemma":0.000298915,"domain_scores_codex":[0.9999032,0.00001763857,0.000006675552,0.00002213575,0.00001708454,0.0000332366],"domain_scores_gemma":[0.99992,0.00001146715,0.00002179992,0.00001237263,0.000008402229,0.00002596734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007800184,0.000004642321,0.0001537694,0.00001314922,0.000001430444,0.00007976133,0.000009848304,0.00006013265,0.9982357,0.0001603005,0.00001195825,0.001191397],"study_design_scores_gemma":[0.0000107612,0.0001058823,0.009256944,0.000004631937,0.00001359466,0.0004963405,0.00003459615,0.0009514054,0.9861469,0.0001740019,0.002798471,0.000006422871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994854,0.001785925,0.00204032,0.00005486262,0.000009875953,0.00000706127,0.0001417717,0.00004894188,0.001057301],"genre_scores_gemma":[0.9974021,0.0005596908,0.0009683454,0.00001461639,0.000005032632,0.000008442519,0.0001357117,0.000009791896,0.0008962631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007117768,"threshold_uncertainty_score":0.002381086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023537233850997,"score_gpt":0.189767876483816,"score_spread":0.169532504145306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}