{"id":"W2069999016","doi":"10.1016/j.cellsig.2010.09.002","title":"Cytoplasmic tail of D1 dopaminergic receptor differentially regulates desensitization and phosphorylation by G protein-coupled receptor kinase 2 and 3","year":2010,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"G protein-coupled receptor kinase; Homologous desensitization; Beta adrenergic receptor kinase; Desensitization (medicine); Phosphorylation; Receptor; Biology; Dopaminergic; Cell biology; Interleukin-13 receptor; Dopamine receptor; G protein-coupled receptor; Internal medicine; Endocrinology; Dopamine; Signal transduction; Biochemistry; Medicine; Insulin-like growth factor 1 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003117281,0.000213712,0.000218554,0.00005312217,0.0001217028,0.00005297326,0.00008836861,0.0002519366,0.00009904822],"category_scores_gemma":[0.00007866388,0.0002091285,0.00005666347,0.00007903589,0.00009459748,0.0000119352,0.0000622374,0.0001440188,0.000002331793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006595549,"about_ca_system_score_gemma":0.00003077952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002049648,"about_ca_topic_score_gemma":0.000006997282,"domain_scores_codex":[0.9987928,0.0000538224,0.0003503922,0.0004362655,0.0001562127,0.0002104655],"domain_scores_gemma":[0.9993262,0.00002134246,0.0002179395,0.0001864251,0.0001396034,0.0001084417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001251233,0.00003418825,0.0001195228,0.00004952688,0.00003053106,7.363737e-7,0.00006468953,0.00006610672,0.9981266,0.0001427128,0.00005640251,0.00118382],"study_design_scores_gemma":[0.0006499707,0.0001929895,0.00001880573,0.00004751821,0.00002525924,0.000002750074,0.00005185811,0.005465501,0.9923587,0.0001306916,0.0008153144,0.0002406587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975022,0.001057634,0.02334361,0.00003424543,0.0001657142,0.000312897,0.00002152041,0.00001735673,0.00002497915],"genre_scores_gemma":[0.9934809,0.000197937,0.005104469,0.0000135547,0.0001594351,0.00001450464,0.0005597335,0.00003905345,0.0004304411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01845883,"threshold_uncertainty_score":0.8528014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003859805296594793,"score_gpt":0.1812084993461172,"score_spread":0.1773486940495224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}