{"id":"W2070003798","doi":"10.1089/dna.2006.0570","title":"Gene Set Enrichment Analyses Revealed Several Affected Pathways in Niemann-Pick Disease Type C Fibroblasts","year":2007,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Biology; NPC1; Downregulation and upregulation; Neurodegeneration; Gene expression; Cell biology; Biological pathway; Cancer research; Drug discovery; Gene; Gene expression profiling; Disease; Bioinformatics; Endosome; Genetics; Internal medicine; Intracellular; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290467,0.0001481438,0.0002845453,0.0001921554,0.00004474058,0.000007179598,0.00007245035,0.0001267012,0.0001638722],"category_scores_gemma":[0.0000961224,0.0001166653,0.00005267466,0.000342865,0.00008763892,0.00002463789,0.00007866762,0.0001639358,0.00004491383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006407889,"about_ca_system_score_gemma":0.00007879093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216615,"about_ca_topic_score_gemma":0.00005515353,"domain_scores_codex":[0.998794,0.000108194,0.0002167603,0.0003377834,0.0001152966,0.0004280006],"domain_scores_gemma":[0.9993443,0.00007936773,0.00004199405,0.0002058074,0.0000614923,0.0002670252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001111839,0.000357921,0.2421506,0.0001786648,0.00005606654,0.0006632206,0.0003413674,0.000009109067,0.7508562,0.00002524333,0.0008265243,0.003423273],"study_design_scores_gemma":[0.003569132,0.001211131,0.9500456,0.00004455094,0.00006633979,0.00002108702,0.000200036,0.0002867971,0.04166481,0.0002171478,0.00239627,0.0002771224],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958062,0.002313139,0.0000596132,0.0001222016,0.00007457341,0.0003364357,0.00001681859,0.00003104306,0.001239962],"genre_scores_gemma":[0.9983675,0.0003394579,0.0001321561,0.0002586237,0.00007851882,0.000008747515,0.0002758423,0.00001242708,0.0005266643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7091914,"threshold_uncertainty_score":0.4757473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0403695096337186,"score_gpt":0.335707353542661,"score_spread":0.2953378439089424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}