{"id":"W2070003798","doi":"10.1089/dna.2006.0570","title":"Gene Set Enrichment Analyses Revealed Several Affected Pathways in Niemann-Pick Disease Type C Fibroblasts","year":2007,"lang":"en","type":"article","venue":"DNA and Cell Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Biology; NPC1; Downregulation and upregulation; Neurodegeneration; Gene expression; Cell biology; Biological pathway; Cancer research; Drug discovery; Gene; Gene expression profiling; Disease; Bioinformatics; Endosome; Genetics; Internal medicine; Intracellular; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002531054,0.0005139734,0.000541639,0.001051391,0.0004868312,0.0004177632,0.0001358871,0.0001573297,0.001984625],"category_scores_gemma":[0.0003298997,0.00008531241,0.0006199305,0.0008699065,0.0002224677,0.00009941972,0.0002593721,0.0003170895,0.0003367015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002506567,"about_ca_system_score_gemma":0.0004804884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002579696,"about_ca_topic_score_gemma":0.004194597,"domain_scores_codex":[0.9997283,0.00002511144,0.00001891291,0.00008930016,0.00007288097,0.0000654059],"domain_scores_gemma":[0.9997912,0.00009492671,0.00002220426,0.00001525098,0.00003877074,0.00003772015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009664763,0.0001058537,0.03567084,0.0003030394,0.0002750567,0.0007664899,0.0001976321,0.001197308,0.9298943,0.0002910822,0.0005351242,0.02979676],"study_design_scores_gemma":[0.00005794805,0.0005674268,0.5722556,0.00004716988,0.000736178,0.002829922,0.0007608239,0.008734385,0.4023634,0.001093187,0.01048093,0.00007305619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846509,0.00114974,0.00585552,0.0001020287,0.00002609736,0.00004888032,0.006578485,0.0002124587,0.001375932],"genre_scores_gemma":[0.9682906,0.001209427,0.01592608,0.0001519681,0.00001390288,0.0001777684,0.009365738,0.00005495585,0.004809714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002579696,"threshold_uncertainty_score":0.006639242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0403695096337186,"score_gpt":0.335707353542661,"score_spread":0.2953378439089424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}