{"id":"W2070030133","doi":"10.1074/jbc.m110.108100","title":"ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice*","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Liver X receptor; Apolipoprotein E; Endocrinology; Internal medicine; Amyloid precursor protein; Presenilin; Genetically modified mouse; Cholesterol; Chemistry; Alzheimer's disease; Medicine; Transporter; Transgene; Biochemistry; Nuclear receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003001061,0.001474154,0.001342876,0.000822979,0.0004296141,0.0006169821,0.0005484468,0.001193169,0.001869943],"category_scores_gemma":[0.0002216164,0.0004913196,0.0007145914,0.0003719513,0.0007535855,0.0006090832,0.0003043924,0.001943636,0.0007920903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005056698,"about_ca_system_score_gemma":0.0005757581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821969,"about_ca_topic_score_gemma":0.003050068,"domain_scores_codex":[0.9996455,0.0000473504,0.00004795829,0.0000546456,0.00005466478,0.0001499309],"domain_scores_gemma":[0.9995963,0.00002925363,0.0001299422,0.00003952263,0.0000337927,0.0001711617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005229279,0.0009632932,0.0003587122,0.0001432122,0.00004260034,0.0003160071,0.00006122574,0.0001141961,0.9885741,0.0001808747,0.0002829179,0.00373367],"study_design_scores_gemma":[0.001325046,0.01669827,0.01724205,0.00007123284,0.0002664125,0.0008150046,0.0002716901,0.001650864,0.9565175,0.000508104,0.004574546,0.00005926539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955872,0.001316028,0.0006359885,0.0003955078,0.00008814215,0.0000633185,0.0006822318,0.000207758,0.00102371],"genre_scores_gemma":[0.9905399,0.001964042,0.001502261,0.0002979925,0.00007498151,0.0002729697,0.0009526259,0.00007464311,0.004320575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869943,"threshold_uncertainty_score":0.006255567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438266859481655,"score_gpt":0.2353262798822213,"score_spread":0.2209436112874048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}