{"id":"W2070030133","doi":"10.1074/jbc.m110.108100","title":"ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice*","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Liver X receptor; Apolipoprotein E; Endocrinology; Internal medicine; Amyloid precursor protein; Presenilin; Genetically modified mouse; Cholesterol; Chemistry; Alzheimer's disease; Medicine; Transporter; Transgene; Biochemistry; Nuclear receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005972598,0.0002053596,0.0004684174,0.00003970923,0.0000727648,0.00001966887,0.0002225328,0.0003411226,0.0001309677],"category_scores_gemma":[0.0006684038,0.00009746796,0.0002242982,0.0001270471,0.0002795154,0.00005171844,0.00003823028,0.001255142,0.000003159664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002811996,"about_ca_system_score_gemma":0.00006500917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000180683,"about_ca_topic_score_gemma":0.00001049718,"domain_scores_codex":[0.9986231,0.00009655514,0.0005375383,0.0002147666,0.0002992535,0.000228743],"domain_scores_gemma":[0.9988045,0.0003537818,0.0004277242,0.0001850857,0.0001050859,0.0001238725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007756223,0.000164818,0.002301607,0.0002239393,0.00004237927,0.00003060652,0.0004996791,7.46356e-7,0.9854418,5.215539e-7,0.00005543834,0.01046282],"study_design_scores_gemma":[0.001849327,0.0002902845,0.05728168,0.0004996894,0.0001125225,0.0001770277,0.0001739654,0.000008930279,0.9382772,0.00004699401,0.001158491,0.0001238416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996887,0.0005740859,7.838358e-7,0.001470648,0.0003622121,0.0004321304,0.00003206181,0.00000826855,0.0002327895],"genre_scores_gemma":[0.9975617,0.0002569627,0.0001067314,0.0001639859,0.001757249,0.00001722479,0.00001447741,0.00001282022,0.0001088765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05498008,"threshold_uncertainty_score":0.5453037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438266859481655,"score_gpt":0.2353262798822213,"score_spread":0.2209436112874048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}