{"id":"W2070043042","doi":"10.1074/jbc.m009172200","title":"Conformational and Temperature-sensitive Stability Defects of the ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator in Post-endoplasmic Reticulum Compartments","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Cystic fibrosis transmembrane conductance regulator; ΔF508; Endoplasmic reticulum; Chloride channel; Cystic fibrosis; Mutant; Mutation; Transmembrane protein; Chemistry; Cell biology; ER retention; Regulator; Biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003501405,0.0001240854,0.0004194952,0.00002454294,0.00003833571,0.00001031121,0.0001044811,0.0001160059,0.0001100964],"category_scores_gemma":[0.001209596,0.00006849896,0.0001159098,0.0001686923,0.0004746185,0.00008103548,0.00003288205,0.0004129829,5.57399e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007917632,"about_ca_system_score_gemma":0.000138206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000245186,"about_ca_topic_score_gemma":0.000002040154,"domain_scores_codex":[0.9987193,0.00008426709,0.0005226192,0.0001349736,0.0003481729,0.0001906567],"domain_scores_gemma":[0.9986971,0.0004368819,0.0002513491,0.0001332955,0.0003461122,0.0001352754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001718136,0.0001397174,0.03074529,0.00017841,0.00003248264,0.00003319698,0.0000688795,0.00001288348,0.9669818,0.00000763472,0.00002223155,0.00005931503],"study_design_scores_gemma":[0.001532556,0.0002915011,0.3392237,0.0002741114,0.00001966475,0.0008715822,0.000279403,0.00005549416,0.6572402,0.00007708471,0.00007645648,0.00005824131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983263,0.0005723928,0.000005332518,0.0005963758,0.00003440241,0.0001945701,0.00005871754,0.000004045237,0.000207886],"genre_scores_gemma":[0.9992186,0.0001222061,0.0005013761,0.00007716882,0.00004270425,0.000002505213,0.00001314637,0.000003821611,0.00001843515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3097417,"threshold_uncertainty_score":0.2793307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832634241619142,"score_gpt":0.269902449969765,"score_spread":0.2515761075535736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}