{"id":"W2070082204","doi":"10.1038/jcbfm.2012.46","title":"Translocator Protein (18 kDa) Polymorphism (rs6971) Explains <i>in-vivo</i> Brain Binding Affinity of the PET Radioligand [ <sup>18</sup> F]-FEPPA","year":2012,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Translocator protein; Radioligand; Positron emission tomography; In vivo; Chemistry; Positron; Molecular biology; Receptor; Biology; Biochemistry; Neuroscience; Genetics; Physics; Immunology; Microglia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001982372,0.0005206812,0.001567998,0.0005078384,0.0001786504,0.00003335681,0.00059737,0.0002520813,0.000726491],"category_scores_gemma":[0.0001462426,0.0003389098,0.0009681504,0.0008220365,0.0002170837,0.0005900862,0.00004166095,0.001181219,0.000008118746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000592128,"about_ca_system_score_gemma":0.0004578858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002974885,"about_ca_topic_score_gemma":0.00002379561,"domain_scores_codex":[0.9955599,0.0002915749,0.001571086,0.0003092316,0.001313785,0.0009544122],"domain_scores_gemma":[0.9976848,0.0001121979,0.0008025958,0.0005758293,0.0002095868,0.0006149582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001884548,0.003267651,0.01678567,0.0007439459,0.001284832,0.000477449,0.006912152,0.0001730748,0.9602118,0.003303475,0.003098373,0.001856992],"study_design_scores_gemma":[0.01620238,0.0003562488,0.0212037,0.001505926,0.0021186,0.001730314,0.001429336,0.00009751672,0.937225,0.0003676405,0.01711603,0.0006473307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878257,0.006059445,0.000257821,0.002742094,0.001047803,0.0008679633,0.00009376425,0.00002781704,0.00107759],"genre_scores_gemma":[0.9915929,0.0001942126,0.004543898,0.000518237,0.001736322,0.00002039515,0.000005516644,0.00009044589,0.001298084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02298687,"threshold_uncertainty_score":0.9999063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537416603798029,"score_gpt":0.2362505388603188,"score_spread":0.2208763728223385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}