{"id":"W2070082204","doi":"10.1038/jcbfm.2012.46","title":"Translocator Protein (18 kDa) Polymorphism (rs6971) Explains <i>in-vivo</i> Brain Binding Affinity of the PET Radioligand [ <sup>18</sup> F]-FEPPA","year":2012,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Translocator protein; Radioligand; Positron emission tomography; In vivo; Chemistry; Positron; Molecular biology; Receptor; Biology; Biochemistry; Neuroscience; Genetics; Physics; Immunology; Microglia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051852,0.0006281096,0.0003402139,0.0004636087,0.0002492993,0.0002672379,0.0001941698,0.0006656852,0.003707644],"category_scores_gemma":[0.000846131,0.0001714419,0.0003761856,0.000357437,0.000358362,0.0001607744,0.0001692406,0.0004052625,0.0005173943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000146668,"about_ca_system_score_gemma":0.0001328472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794626,"about_ca_topic_score_gemma":0.001294068,"domain_scores_codex":[0.9997546,0.00006248862,0.00002760599,0.00008286721,0.00003288766,0.00003954179],"domain_scores_gemma":[0.9995239,0.0001944693,0.0001780298,0.00003751876,0.0000248364,0.00004130497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004730011,0.0003558504,0.3451734,0.0001203951,0.0006284353,0.006789464,0.0004436704,0.001091233,0.6199939,0.001012197,0.001105897,0.01855565],"study_design_scores_gemma":[0.0001221116,0.000627015,0.9374079,0.00002104284,0.0004936718,0.01836645,0.0001915796,0.002776962,0.0367738,0.001128274,0.002053488,0.00003780771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980698,0.000207481,0.0009593821,0.0001311207,0.00001250685,0.000007248107,0.0001815911,0.00002446192,0.0004064147],"genre_scores_gemma":[0.9991954,0.00007102979,0.0003428609,0.00002874983,0.00001752224,0.000004978102,0.0001234056,0.00001739974,0.0001987059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003707644,"threshold_uncertainty_score":0.01240331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537416603798029,"score_gpt":0.2362505388603188,"score_spread":0.2208763728223385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}