{"id":"W2070090261","doi":"10.1016/s0168-8278(10)60034-7","title":"32 A PHASE 1, MULTI-CENTER, RANDOMIZED, PLACEBO-CONTROLLED, DOSE-ESCALATION STUDY OF IMO-2125, A TLR9 AGONIST, IN HEPATITIS C-NONRESPONDERS","year":2010,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; University of British Columbia","funders":"","keywords":"Medicine; Placebo; Agonist; Center (category theory); TLR9; Internal medicine; Virology; Gastroenterology; Chemistry; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001888628,0.001713971,0.002535248,0.0005240606,0.0005944726,0.000688503,0.0006379362,0.001646702,0.004610008],"category_scores_gemma":[0.00127601,0.000979773,0.001705275,0.0003539833,0.0007530624,0.0006690383,0.0003434208,0.003282391,0.0007975568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006030302,"about_ca_system_score_gemma":0.001141717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789525,"about_ca_topic_score_gemma":0.002377823,"domain_scores_codex":[0.9994272,0.0003059524,0.00003353921,0.00009367256,0.00003837896,0.0001012743],"domain_scores_gemma":[0.9994904,0.0001243978,0.00008440923,0.00005480631,0.00003877619,0.0002073464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9175837,0.02188356,0.00149471,0.0007815543,0.0009967007,0.0001048877,0.0001228255,0.0008108708,0.01993955,0.0001679384,0.001404095,0.03470957],"study_design_scores_gemma":[0.9241587,0.07161077,0.002055557,0.00001801011,0.0003013763,0.00004398635,0.00001838428,0.0003524402,0.0007303616,0.00009747515,0.000593534,0.00001922605],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868334,0.002157633,0.001035721,0.0007665738,0.0002774238,0.006593008,0.0009933549,0.0001370073,0.001205945],"genre_scores_gemma":[0.9837673,0.001458111,0.004064254,0.00138709,0.0002076427,0.005167136,0.00103892,0.00002872366,0.002880788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004610008,"threshold_uncertainty_score":0.01542199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03608226067537807,"score_gpt":0.3855890765694095,"score_spread":0.3495068158940314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}