{"id":"W2070132291","doi":"10.1074/jbc.m313156200","title":"Cofactor Hydrogen Bonding onto the Protein Main Chain Is Conserved in the Short Chain Dehydrogenase/Reductase Family and Contributes to Nicotinamide Orientation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Medical Research Council; Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"Nicotinamide; Cofactor; Chain (unit); Chemistry; Reductase; Hydrogen bond; Biochemistry; NAD+ kinase; Dehydrogenase; Enzyme; Stereochemistry; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001234706,0.0001501415,0.0002328743,0.00002216478,0.0001361651,0.00007544178,0.0002757375,0.0001322488,0.00003478016],"category_scores_gemma":[0.0003985444,0.00007413406,0.00007217505,0.0001764579,0.0001470646,0.00007206234,0.00004776947,0.0002512291,0.000002491088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267805,"about_ca_system_score_gemma":0.00007032849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003424038,"about_ca_topic_score_gemma":0.00001436954,"domain_scores_codex":[0.9987932,0.0001164195,0.0004389252,0.0001995112,0.000209639,0.0002423315],"domain_scores_gemma":[0.9993925,0.0001258374,0.0001851927,0.0001459432,0.00006506877,0.00008544722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002047057,0.0000367781,0.001317246,0.00001174575,0.00000993474,0.00002702559,0.000307096,0.00003108233,0.9976489,0.0001853278,0.000160897,0.00005929292],"study_design_scores_gemma":[0.0005386084,0.0001583722,0.004187914,0.00005975971,0.00001472609,0.0001562214,0.001379246,0.00000637394,0.9899651,0.002864715,0.0005665866,0.0001023735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957258,0.000510238,0.0001641233,0.003108781,0.0000857503,0.0002858818,0.00003458917,0.000009298523,0.00007551238],"genre_scores_gemma":[0.9984025,0.00001606017,0.0001977437,0.001139659,0.0001919735,0.00001800617,0.00000687064,0.000005223356,0.00002191284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007683765,"threshold_uncertainty_score":0.3023099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.021324759619868,"score_gpt":0.2507235955269124,"score_spread":0.2293988359070444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}